Objective: Aggressive periodontitis (AgP) is frequently associated with the presence of Aggregatibacter actinomycetemcomitans, a Gram-negative pathogen, which expresses leukotoxin (Ltx) as a virulence factor. Ltx is known to disturb neutrophil function and to activate these cells. This study was aimed at investigating the ability of Ltx to alter the chemotactic behaviour of neutrophils, the mos...

lent work. Everyone with anything to do with Dictyoste-Wackett and Hershberger have summarized over 90 functional groups in organic molecules, ranging from lium should read this. Scientists who are wondering simple alcohols to tricycloaliphatic rings. Microbes are whether or not to dip their toes will get a better idea of known to have strategies for dealing with 58 of these. whether social amo...

The first attempt of treating patients affected by knee osteoarthritis with arthroplasty go back up to the mid-nineteenth century with the use of either a soft tissue interposed within the joint surface or resection of a different amount of bone of both distal femur and proximal tibia. However the concept on which total joint replacement is based can be traced only after the 1880 in Berlin with...

WASP takes the sting out of SCAR mutants V eltman et al. reveal how one actin regulator can fi ll in for another to maintain cell protrusion and migration. The Arp2/3 complex stimulates actin assembly at several different sites within the cell. WASP family proteins activate the complex at clathrin-coated pits undergoing endocytosis, whereas SCAR/WAVE proteins stimulate Arp2/3's activity at the ...

realign the knee extensor mechanism. Proximally, Insall realignment or variations with imbrication of the vastus medialis obliquis (VMO) and medial patellar retinaculum, combined with a lateral release, have been used extensively to improve patellar tracking. Distal realignment, in which the tibial tubercle is typically moved medially to improve patellar alignment, is the other common approach ...

Frequency of knee joint osteoarthritis has been growing over the last years. Range of degeneration involvement of the knee joint varies from unicompartmental to tricompartmental. The medial part of the knee is damaged most frequently. The solution of serious knee joint degeneration is a total replacement by endoprosthesis. It is indicated not only in the case of idiopathic gonarthrosis, but als...

Two papers in this issue of The Journal of Cell Biology uncover a possible new connection between the actin-nucle-ating complex of proteins, the Arp2/3 complex, and the type I myosin motors. In this issue, Lechler et al. (2000) and Evangelista et al. (2000) show a direct interaction of the S. cerevisiae myosin I motors (Myo3p and Myo5p) with the Arp2/3 complex through an acidic COOH-terminal se...

We reviewed the results of sixty-one McKeever unicompartmental arthroplasties performed by the senior one of us (T. P.) for osteoarthritis of the knee. The average follow-up was five years (range, two to thirteen years). Forty-four (72 per cent) of the arthroplasties were rated as good to excellent. The average postoperative range of motion in these knees was 110 degrees. Six knees were rated a...