Extrarenal disposal of potassium load is impaired in chronic renal failure (CRF). This has been attributed to excess PTH since extrarenal disposition of potassium is normal in CRF-PTX animals. Insulin augments potassium entry into cells and hyperkalemia stimulates insulin secretion. Since glucose-induced insulin secretion is impaired in CRF and normal in CRF-PTX, it is possible that K(+)-induce...

The electrophysiological and metabolic responses to insulin of skeletal muscles from control and potassium-depleted rats were compared. Membrane potentials, action potentials, contraction parameters as well as oxygen uptake were measured in diaphragm strips or intact extremity muscles from the two groups, and similar measurements were made in vivo. The muscles were examined in solutions with no...

Program pemuliaan tanaman dapat lebih efektif dan efisien jika terdapat informasi pewarisan sifat dari karakter yang akan dimuliakan. Namun, belum semua kualitatif pada buah tomat diketahui pola sifatnya. Penelitian ini bertujuan untuk memperoleh tentang beberapa tomat. dilakukan Januari – April 2020 di Kebun Percobaan IPB Leuwikopo, Bogor, Indonesia. Sebanyak 10 varietas Tora IPB, genotype GIK...

On-site mortality in crush syndrome remains high due to lack of effective drugs based on definite diagnosis. Anisodamine (Ani) is widely used in China for treatment of shock, and activation of α7 nicotinic acetylcholine receptor (α7nAChR) mediates such antishock effect. The present work was designed to test whether activation of α7nAChR with Ani decreased mortality in crush syndrome shortly aft...

Understanding mechanisms by which glibenclamide stimulates insulin release is important, particularly given recent promising treatment by glibenclamide of permanent neonatal diabetic subjects. Antidiabetic sulfonylureas are thought to stimulate insulin secretion solely by inhibiting their high-affinity ATP-sensitive potassium (K(ATP)) channel receptors at the plasma membrane of beta-cells. This...

The change in transmembrane potential of rat adipocytes was measured using the fluorescent probe 3,3'-diethylthiadicarbocyanine iodide, diS-C2-(5). The method was calibrated by altering the potassium ion concentration while keeping the sum of potassium and sodium ions at a constant concentration of 153 mM (Bailey et al: Bioelectrochem. Bioenergetics 21:333-42, 1989). Two insulin-mimetic agents,...

To define the role of insulin in blood pressure regulation, the hormone's action on renal sodium handling, potassium balance, pressor reactivity, and the release of catecholamines and aldosterone are summarized. Insulin-stimulated renal sodium reabsorption induces expansion of the extracellular volume, increase in cardiac output, and ultimately, hypertension. On the other hand, the insulin-indu...

Hyperkalaemia, an elevated extracellular fluid potassium concentration, is a common electrolyte disorder and is present in 1-10% of hospitalised patients. Elevated serum potassium concentrations are usually asymptomatic but may be associated with electrocardiogram (ECG) changes. Hyperkalaemia occasionally leads to life-threatening cardiac arrhythmias. Prompt recognition of this disorder, patien...

På DFFU’s initiativ skrev en arbejdsgruppe i 2012 rapport, der gennem ni scenarier spår forskningsbibliotekernes fremtid 10 år frem. Medlemmer af arbejdsgruppen gennemgår her, hvilke ramte plet eller skød forbi – og pejler sig ind på bibliotekernes bæredygtige fremtid.