Berberine-containing plants are used medicinally in virtually all traditional medical systems, and have a history of usage in Ayurvedic and Chinese medicine dating back at least 3,000 years. Berberine has demonstrated significant antimicrobial activity against bacteria, fungi, protozoans, viruses, helminths and chlamydia. In addition, berberine’s actions include: antagonism of the effects of ch...

rivation of blood flow to the brain, results in the insidious delayed degeneration of specific vulnerable neurons within the hippocampus. Among hippocampal neurons, pyramidal cells of the hippocampal CA1 region are most vulnerable to cerebral ischemia. Death of the CA1 pyramidal cells following cerebral ischemia causes a variety of neurological dysfunction such as depression and memory deficits...

The widespread Berberis trifoliolata is sympatric with the narrowly restricted B. swaseyi in central Texas, where apparent intermediates occur. A detailed field study of sympatric populations in northern Hays Co. during 2004 to 2007 clarifies the morphological and phenological differences between the two species and shows that intermediates almost surely arose from hybridization. Limited eviden...

The aqueous methanolic extract of stem part of Berberis calliobotiys (AMEBC) was evaluated for anti-inflammatory, analgesic and antipyretic activities in albino mice. Anti-inflammatory activity was evaluated by using carrageenan and albumin induced paw edema, while the analgesic effect was assessed by using formalin-induced paw licking and acetic acid induced abdominal writhing in mice. The bre...

seedless barberry (berberis vulgaris l. var. asperma) is one of the few crops that is only cultivated in eastern parts of iran. as a new crop there has not been any study to identify phylogenetic relationships of this plant with other related species existing in iran. in this study, amplification fragment length polymorphism (aflp) markers based on four selected primer combinations (ecori/tru1i...

The incidence of fungal infections and, in particular, the incidence of fungal antibiotic resistance, which is associated with biofilm formation, have significantly increased, contributing to morbidity and mortality. Thus, new therapeutic strategies need to be developed. In this context, natural products have emerged as a major source of possible antifungal agents. Berberine is a protoberberine...

A bioassay-guided fractionation and chemical investigation of the trunk of Berberis koreana led to the isolation and identification of three new triterpenoids, 2 α,3 α,19 α-trihydroxy-urs-12-en-24-formyl-28-oic acid (1), 2 α,3 β,21 α-trihydroxy-urs-12-en-28-oic acid ( 2), and 3 β-acetyloxy-1-oxo-olean-12-en-28-oic acid (3), along with seven known triterpenoids (4-10). The structures of these ne...