Molecular recognition is a highly interdependent process. Subsite couplings within the active site of proteases are most often revealed through conditional amino acid preferences in substrate recognition. However, the potential effect of these couplings on inhibition and thus inhibitor design is largely unexplored. The present study examines the interdependency of subsites in HIV-1 protease usi...

Impaired myocardial performance is known to be associated with electrical and mechanical beat-to-beat alternans phenomena. The alternans in blood pressure and heart rate and their interdependency in idiopathic dilated cardiomyopathy (IDC) were studied. The arterial blood pressure and the electrocardiograph (ECG) were continuously recorded in 22 patients suffering from IDC (age 49 +/- 13 years, ...

• Resilience should be used as a complementary metric to vulnerability and risk. Interdependency assessment highlights hidden vulnerabilities. Higher level of interdependencies exposes networks higher vulnerability. Interdependencies creates greater opportunities for shared interventions. The common challenge currently faced by critical infrastructure (CI) asset owners operators is the lack an ...

In this work we present a methodology to express both analytically and graphically the interdependencies among tasks realized in a collaborative environment. For each interdependency expression, a coordination mechanism is built, modeling the global behavior of the environment, i.e., the structure that ensures the realization of the tasks according to the established interdependencies.

A critical element to successful command and control (C 2) is developing and updating an accurate and lucid model of the interdependencies between functional units, e.g., multiple platoons of artillery and tanks. Two of the challenges to this understanding are (1) the adoption of a detailed description of interdependency and the associated understanding of interdependent functions (Brehmer, 200...

Alternatives are needed to using intuition as the dominant approach for assessing critical infrastructure interdependencies. Since there is no single, measurable unit that accurately reflects interdependencies between critical infrastructure sectors, an interdependency metric must be a composite of measurable elements related to the dependency of one sector on another. This paper defines and ap...

In this paper, we develop an accurate dynamic thermal management DTM approach considering the interdependency of temperature and leakage. By modeling the leakage-thermal interdependence as a quadratic polynomial, we develop accurate analytical equations that capture the thermal transient. We also identify all the situations in which thermal runaway would occur, which should be avoided by DTM. W...