نتایج جستجو برای: interferon receptor
تعداد نتایج: 644919 فیلتر نتایج به سال:
conclusions this study supports the idea that the ifnl3 gene is an important predictor of the response of chb patients to ifn therapy. results nine studies of 1602 chb patients receiving ifn treatment were included. under the random-effects model, patients expressing the variant rs12980275 showed a significantly increased response to ifn therapy (or = 2.85; 95% ci = 1.14 - 4.60). in the subgrou...
The scavenger receptor (ScR) mediates uptake of chemically modified low density lipoprotein (LDL) by human monocytederived macrophages. It is not down-regulated by high intracellular cholesterol levels, and exposure of macrophages to acetylated or oxidized LDL therefore leads to foam cell development. The hypothesis that this represents an important mechanism for intracellular cholesterol accum...
Recent reports describe the beneficial use of alpha interferon (IFNa) for the treatment of idiopathic hypereosinophilic syndrome (HES) unresponsive to conventional therapy. A clinical improvement associated with a rapid decrease of peripheral blood eosinophilia suggested possible direct effects of IFNa on eosinophils through the presence of lFNa receptors (IFNaR). Reverse transcriptase-polymera...
To identify novel cytokine-related genes, we searched the set of 60,770 annotated RIKEN mouse cDNA clones (FANTOM2 clones), using keywords such as cytokine itself or cytokine names (such as interferon, interleukin, epidermal growth factor, fibroblast growth factor, and transforming growth factor). This search produced 108 known cytokines and cytokine-related products such as cytokine receptors,...
Viruses induce double-stranded RNA (dsRNA) in the host cells. The mammalian system has developed dsRNA-dependent recognition receptors such as RLRs that recognize the long stretches of dsRNA as PAMPs to activate interferon-mediated antiviral pathways and apoptosis in severe infection. Here we report an efficient antiviral immune response through dsRNA-dependent RLR receptor-mediated necroptosis...
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