نتایج جستجو برای: interferon regulatory factor 7 irf7

تعداد نتایج: 1617638  

Journal: :The Journal of biological chemistry 2011
Jennifer A Young Decha Sermwittayawong Hee-Jung Kim Suruchi Nandu Namsil An Hediye Erdjument-Bromage Paul Tempst Laurent Coscoy Astar Winoto

The production of cytokines such as type I interferon (IFN) is an essential component of innate immunity. Insufficient amounts of cytokines lead to host sensitivity to infection, whereas abundant cytokine production can lead to inflammation. A tight regulation of cytokine production is, thus, essential for homeostasis of the immune system. IFN-α production during RNA virus infection is mediated...

2010
Rie Miyamoto Tomoki Ito Shosaku Nomura Ryuichi Amakawa Hideki Amuro Yuichi Katashiba Makoto Ogata Naoko Murakami Keiko Shimamoto Chihiro Yamazaki Katsuaki Hoshino Tsuneyasu Kaisho Shirou Fukuhara

INTRODUCTION Plasmacytoid dendritic cells (pDCs) play not only a central role in the antiviral immune response in innate host defense, but also a pathogenic role in the development of the autoimmune process by their ability to produce robust amounts of type I interferons (IFNs), through sensing nucleic acids by toll-like receptor (TLR) 7 and 9. Thus, control of dysregulated pDC activation and t...

Journal: :The Journal of Experimental Medicine 2005
Grégory Gautier Martine Humbert Florence Deauvieau Mathieu Scuiller John Hiscott Elizabeth E.M. Bates Giorgio Trinchieri Christophe Caux Pierre Garrone

Dendritic cells (DC) produce interleukin-12 (IL-12) in response to Toll-like receptor (TLR) activation. Two major TLR signaling pathways participate in the response to pathogens: the nuclear factor-kappaB (NF-kappaB)-dependent pathway leading to inflammatory cytokine secretion including IL-12 and the interferon (IFN)-dependent pathway inducing type I IFN and IFN-regulated genes. Here we show th...

2011
Silvia Rasi Gianluca Gaidano

Other names: IRF-4; NF-EM5; LSIRF (lymphocytespecific interferon regulatory factor); MUM1 (multiple myeloma oncogene 1) HGNC (Hugo): IRF4 Location: 6p25.3 Local order: IRF4 is located on chromosome 6 at the telomeric extremity of the short arm, and lies between the DUSP22 (dual specificity phosphatase 22) and EXOC2 (exocyst complex component 2) genes. Note: IRF4 belongs to the IRF (interferon r...

Journal: :Fish & shellfish immunology 2010
Guobin Hu Xiangyan Yin Jun Xia Xianzhi Dong Jianyie Zhang Qiuming Liu

Interferon regulatory factor (IRF) 7 in mammals is known to be a key player in regulating the type I interferon (IFN) response to viral infection as a transcription activator of IFNs and IFN-stimulated genes (ISGs). In this study, a full-length cDNA of Japanese flounder, Paralichthys olivaceus, (Po)IRF-7 was cloned and characterized. PoIRF-7 is 2032 bp in length, with an open reading frame (ORF...

Journal: :Cell reports 2017
Aaron F Carlin Emily M Plummer Edward A Vizcarra Nicholas Sheets Yunichel Joo William Tang Jeremy Day Jay Greenbaum Christopher K Glass Michael S Diamond Sujan Shresta

Interferon-regulatory factors (IRFs) are a family of transcription factors (TFs) that translate viral recognition into antiviral responses, including type I interferon (IFN) production. Dengue virus (DENV) and other clinically important flaviviruses are suppressed by type I IFN. While mice lacking the type I IFN receptor (Ifnar1-/-) succumb to DENV infection, we found that mice deficient in thr...

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