PURPOSE The purpose of this report was to retrospectively evaluate implant and immediate full-arch prosthesis survival rates over a 24-month period; patients were consecutively treated with immediate occlusal loading. Dental arch, gender, and implant orientation (vertical vs. tilted) were also noted. MATERIALS AND METHODS All Brånemark System implants (Nobel Active) and interim, all-acrylic r...

3578 Background: The combination of high-dose irinotecan (260mg/m2) with LV5FU2 (FOLFIRI HD regimen) is feasible with an acceptable safety profile and promising efficacy data (Ducreux et al. Oncology 2008;74:17-24). The aim of this phase II study was to evaluate the combination of FOLFIRI HD plus bevacizumab (B) in patients (pts) selected on the UGT1A1 polymorphism, which could be predictive of...

Adoption of newly available materials and knowledge, through trial and error experiment, sometimes can result in an increase of productivity as well as improvement of quality. This is often true in industry in general, and can also be true in the prosthetic field . This paper describes a fabrication system combining many widely used techniques (2,4,5,6) and accepted principles (3) and a few new...

Hodgkin lymphoma (HL) is a curable disease with currently available chemotherapy regimens. Major late morbidities can potentially be avoided in most limited-stage HL patients if the treatment can be adapted to the patient's early response profile. The therapy efficacy can also be increased early during therapy in nonresponding HL patients with the addition of involved-field radiation therapy or...

Interim sample size re-estimation (SSR) often affects the Type I and II error rates. We propose and investigate a method based on resampling the whole study design at the interim analysis. This resampling starts with SSR at the observed interim analysis values of nuisance parameters and finishes with the decision to accept or reject the null hypothesis. The proposed approach finds a new critica...

Twice each year the World Health Organization makes a recommendation for the composition of the influenza vaccine, based on circulating strains of influenza A(H3N2), A(H1N1) and B. Strain selection has always been based on immunogenicity studies with limited human data. Immunogenicity can be considered as a proxy for vaccine effectiveness (VE). However, only interim VE estimates for the target ...

We look at a principal–agent model in which the agent has to perform an action, the difficulty of which is better known ex interim than ex ante. We compare two contracting regimes; one with commitment to an ex ante negotiated contract, and one with an ex interim negotiated contract. The ex ante contract can not be too steep, but attempts to negotiate a steeper ex interim contract may result in ...

The IIVOP trial is a cross-over trial which examines the effect of the drug ivabridine in reducing pain in an enriched healthy volunteer pain model. The trial was designed based on very limited information, and as such an interim analysis was built into the design to allow the re-estimation of the sample size requirements based on updated trial parameters. The blinded data will be used to asses...

I examine the implementation of core allocations when agents are differently informed. A one state deviation principle (an allocation cannot be improved at any state) and measurability restrictions (blocking allocations may only be measurable with respect to each agent’s private information) are sufficient to yield interim core solutions that are Bayesian implementable. Private measurability of...

We determine the sensitivities of the EVLA and VLA antennas over their full tuning ranges through analysis of the correlation coefficients. Interim EVLA antennas can tune over the full range of 940 through 2200 MHz. The prototype L-band OMT shows good performance over its design frequency range. The betterperforming interim EVLA antennas meet the Project Book sensitivity requirements above ∼115...