نتایج جستجو برای: interleukin 1 receptor antagonist protein

تعداد نتایج: 3928682  

Journal: :Frontiers in Neurology 2023

Background Generalized convulsive epilepsy (GCE), an important subtype of epilepsy, is a syndrome neuronal dysfunction characterized by diffuse abnormal discharge neurons within the brain. Compounding evidence suggests correlation between and inflammatory factors, for instance, cyclooxygenase-2, interleukin-1β, interleukin-6. Elevated levels factors have been observed in patients with several a...

Journal: :IUPHAR/BPS guide to pharmacology CITE 2021

Adenosine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Receptors [110]) are activated endogenous ligand adenosine (potentially inosine also at A3 receptors). Crystal structures for antagonist-bound [153, 313, 221, 61], agonist-bound [375, 203, 204] and G protein-bound A2A [49] have been described. The of an A1 receptor [128] adenosine-bound receptor-Gi complex [86] resolve...

Journal: :Analytical Chemistry 2021

Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) is a robust and powerful tool for studying biomacromolecules their interactions. However, quantitative detection of high-mass analytes (kDa to MDa range) remains challenging MALDI-MS. Herein, we successfully used commercially available purified proteins (?-galactosidase BSA) as internal standards MALDI-MS analysis achieved...

1998
Heinz Gulle Aysen Samstag Martha M. Eibl

In this report, we show that the Src family nonreceptor protein tyrosine kinase (PTK) Lyn associates with aggregated IgA Fc receptor (FcaR) in the monocytic cell line THP-1. Receptor aggregation and subsequent immunoprecipitation of receptor complexes with huIgA adsorbed to nitrocellulose particles shows that Lyn associates with FcaR by a mechanism sensitive to short treatment with the Src fami...

2016
Samaneh Maysami Raymond Wong Jesus M Pradillo Adam Denes Hiramani Dhungana Tarja Malm Jari Koistinaho Cyrille Orset Mahbubur Rahman Marina Rubio Markus Schwaninger Denis Vivien Philip M Bath Nancy J Rothwell Stuart M Allan

Stroke represents a global challenge and is a leading cause of permanent disability worldwide. Despite much effort, translation of research findings to clinical benefit has not yet been successful. Failure of neuroprotection trials is considered, in part, due to the low quality of preclinical studies, low level of reproducibility across different laboratories and that stroke co-morbidities have...

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