insulin-loaded biodegradable chitosan nanoparticle was prepared by the polyelec-trolyte complex formation method. the prepared nanoparticles were in the size of 110 nm and had high entrapment (91.0%) capacity. the transdermal nanoinsulin was characterized by in vivo hypoglycemic effects. plasma glucose was decreased to the range of 80.34 to 96.74 mg/dl, and insulin levels were increased to the ...

background: according to previous studies, most of the speech recognition disorders in older adults are the results of deficits in audibility and auditory temporal resolution. in this paper, the effect of ageing on timecompressed speech and auditory temporal resolution by word recognition in continuous and interrupted noise was studied. methods: a time-compressed speech test (tcst) was conducte...

Evaluating quality improvement interventions requires a variety of methods. These range from quantitative methods, such as randomised controlled trials, to quasi-experimental (controlled before-and-after and interrupted time series) and uncontrolled before-and-after studies, including clinical audits, to determine whether improvement interventions have had an effect. Qualitative methods are oft...

Transdermal drug delivery system offers best way of through skin than compared to oral route administration by overcoming side-effects.Drug is done adhesion transdermal patches surface.Novel application techniques have been employed for better therapeutic response various in treatment several disease using dermal administration.This non-invasive method reducing frequency achieve complete action...

BACKGROUND In uncontrolled before-after studies, CONSORT was shown to improve the reporting of randomised trials. Before-after studies ignore underlying secular trends and may overestimate the impact of interventions. Our aim was to assess the impact of the 2007 STROBE statement publication on the quality of observational study reporting, using both uncontrolled before-after analyses and interr...

Postoperative management of pain has traditionally utilized intravenous (IV) morphine for pain control. An alternative approach to the invasive patient-controlled analgesia (PCA) system is the administration of transdermal analgesics, such as fentanyl. In 2006 the Food and Drug Administration (FDA) approved the fentanyl hydrochloride (fentanyl HCl) iontophoretic transdermal system (ITS), which ...

The aim of this study was to evaluate the transdermal permeation of alniditan by electroporation and to compare with iontophoretic delivery. The influence of the electrical parameters of electroporation was investigated in vitro using a factorial design study. The transdermal flux of alniditan was enhanced by two orders of magnitude by application of high voltage electrical pulses. The electric...

objective(s):the objective of this study was to find a stable microemulsion vehicle for transdermal delivery of ibuprofen to improve the skin permeability. materials and methods: microemulsion was prepared using different sorts of oils, surfactants and co-surfactants. pseudo-ternary phase diagrams were used to evaluate the microemulsion domain. the effects of oleic acid and surfactant mixture o...

abstract background: acute opium intoxication is one of the most common causes of poisoning in children in iran. although most cases are accidental, traditional misuse of opium for symptomatic therapy of various childhood diseases also contributes to high rate of opium intoxication in iran. cases: here, we report two cases of opium intoxication in infants resulted from transdermal application o...

introduction methanol is a highly toxic substance and methanol poisoning results in severe health situations. methanol poisoning occurs when it is consumed by various methods such as orally, by inhalation, and transdermally. transdermal poisoning is rarely seen and causes severe health complications. conclusions methanol poisoning presents to the emergency department in our country with many di...