PURPOSE To evaluate the feasibility and usefulness of imipenem/cilastatin sodium (IPM/CS) as an embolic agent for intestinal bleeding from neoplasms. MATERIALS AND METHODS Seven patients who underwent 11 transarterial embolisations (TAEs) using IPM/CS as an embolic material for duodenal or small/large intestinal tumour bleeding from January 2004 to December 2011 were retrospectively evaluated...

BACKGROUND/AIMS Proton pump inhibitors (PPIs) are widely used to prevent nonsteroidal anti-inflammatory drug (NSAID)-induced peptic ulcers. NSAIDs produce small intestinal injury and some PPIs have been reported to protect against NSAID-induced small bowel injury in rats. The aim of this study was to compare PPIs, revaprazan, and phosphatidylcholine-associated indomethacin (Indo-PC) for protect...

Imatinib mesylate is a widely used tyrosine-kinase inhibitor (TKI) in chronic myeloid leukemia (CML) treatment. Imatinib has contributed to complete and prolong cytogenetic responses so that it is now the standard treatment of CML. Recently, Imatinib mesylate has shown a significantly prolonged progression-free survival and overall survival in metastatic and locally advanced c-Kit positive gast...

Symptomatic Meckel's Diverticulum is a rare entity in old patients. The most common complications are gastrointestinal bleeding, intestinal obstruction, acute inflammation, and perforation. Usually those complications occur on the first two decades of life and mostly before the fifth decade. We report an extremely unusual debut of Meckel's Diverticulum, presented as massive spontaneous hemoperi...

Celiac disease is a gluten-sensitive enteropathy that occurs in genetically predisposed individuals. Patients with the disease must adhere to a strict gluten-free diet. However, not all patients respond promptly to the diet, and some develop symptoms while on the diet. The presence of persistent abdominal pain and blood detected in the stool raise the possibility of complications such as small ...

Objective: To evaluate the relationship between topically applied non-steroidal antiinflammatory drugs and upper gastro-intestinal bleeding and perforation. Study population: The population of 319,465 people who were resident in Tayside and were registered with a Tayside GP between January 1989 and October 1994. A recordlinkage database containing all hospital event and dispensed drug data betw...

Clinical relapse of inflammatory bowel disease is characterised by increased neutrophil migration into the intestine. The site of the neutrophil chemoattractant(s), whether luminal or mucosal, may be important since, on contact with a chemoattractant, neutrophils cause indiscriminate damage to their immediate surroundings by generating reactive oxygen species and by lysosomal enzyme release. If...

Of 776 patients admitted as emergency with acute upper gastro-intestinal haemorrhage, 260 were operated for uncontrollable bleeding. At surgery the cause of bleeding could not be determined in 42 (15%) cases. Vagotomy and drainage was done in 30 and gastric resection in 1 2 cases. Two patients died after gastrectomy (2/12). Follow up of 38 cases for 5 years showed good results. Two cases were l...

A 54-year-old woman presented a massive hematochezia 7 days after sigmoidectomy. Repeated colonoscopy and angiography failed to locate the site of bleeding and Hartman's operation was performed. Rebleeding from the rectum on the day of operation occurred and pulsate arterial bleeding with minimal surrounding ulcer 1 cm above the pectinate line was observed. Screlotherapy with ethanol and electr...

A 43-year-old woman presented with acute lower intestinal bleeding requiring blood transfusion. Multiple initial investigations did not reveal the cause of the bleeding. Colonoscopy performed 2 days later showed features suggestive of ischemic colitis. On detailed history, the patient admitted to using amphetamines, and her urine drug screen was positive for them. She was managed conservatively...