Intracellular pathogens are microorganisms that traverse the plasma membrane of a particular host cell...

introduction: we have recently reported the presence of two potassium currents with 598 and 368 ps conductance in the rough endoplasmic reticulum (rer) membrane. the 598 ps channel was voltage dependent and atp sensitive. however, the 368 ps channel was rarely observed and its identity remained obscure. since cationic channels in intracellular organelles such as mitochondria and rer play import...

Intracellular transport is the process by which cellular cargos, such as organelles and proteins, are moved throughout the cell. Motor proteins bind these cargos and walk along microtubule tracks to deliver them to specific regions of the cell. In axons, cargos are transported by either fast or slow axonal transport. Fast axonal transport is performed by fixed teams of motors bound to membranou...

A theory is presented that deals with the involvement of the intracellular binding proteins ligandin and aminoazodye-binding protein A (otherwise known as Z-protein or fatty-acid-binding protein) on the uptake and intracellular transport and metabolism of their ligands. Equations are derived that combine steady-state diffusional fluxes of small molecules that are (a) free in the aqueous phase o...

Intracellular transport of DNA carriers is a fundamental step of gene delivery. By combining both theoretical and numerical approaches we study here single and several viruses and DNA particles trafficking in the cell cytoplasm to a small nuclear pore. We present a physical model to account for certain aspects of cellular organization, starting with the observation that a viral trajectory consi...

Protein-directed intracellular transport has not been observed in bacteria despite the existence of dynamic protein localization and a complex cytoskeleton. However, protein trafficking has clear potential uses for important cellular processes such as growth, development, chromosome segregation, and motility. Conflicting models have been proposed to explain Myxococcus xanthus motility on solid ...

Intracellular transport in plant cells occurs on microtubular and actin arrays. Cytoplasmic streaming, the rapid motion of plant cell organelles, is mostly driven by an actin-myosin mechanism, whereas specialized functions, such as the transport of large cargo or the assembly of a new cell wall during cell division, are performed by the microtubules. Different modes of transport are used, fast ...

This paper presents a modeling study for the intracellular trafficking and trimerization of the HIV-1 Gag proteins. A set of differential equations including initial and boundary conditions is used to characterize the transport, diffusion, association and dissociation of Gag monomers and trimers for the time period from the initial production of Gag protein monomers to the initial appearance of...

Optical quantification of intracellular mass density using optical diffraction tomography (ODT) and cell mechanics Brillouin spectroscopy under 3D mechanical confinement.

Particles moving along curved trajectories will diffuse if the curvature fluctuates sufficiently in either magnitude or orientation. We consider particles moving at a constant speed with either a fixed or a Gaussian distributed magnitude of curvature. At small speeds the diffusivity is independent of the speed. At larger particle speeds, the diffusivity depends on the speed through a novel expo...