The interactions of DNA with oxaliplatin (Pt(R,R-DACH)) or its enantiomer (Pt(S,S-DACH)) were investigated using magnetic tweezers and atomic force microscope. In the process of DNA condensation induced by Pt-DACH, only diadducts and micro-loops are formed at low Pt-DACH concentrations, while at high Pt-DACH concentrations, besides the diadducts and micro-loops, long-range cross-links are also ...

We report the development of an automated chemical reactor for solid-phase synthesis of MIP NPs in water. Operational parameters are under computer control, requiring minimal operator intervention. In this study, "ready for use" MIP NPs with sub-nanomolar affinity are prepared against pepsin A, trypsin and α-amylase in only 4 hours.

Periodic organic-inorganic multilayer films are constructed by stepwise alternate build-up of UV-stabilized poly(styrene-block-vinylpyridine) block copolymer inverse micelles and poly(styrene-block-ethylene oxide) block copolymer layers containing inorganic moieties at the polar core blocks. The layered block copolymer inverse micelle films show strong reflective color and well-defined photonic...

A set of enantiomerically pure cyclic multinuclear complexes with the formula cis-[a(2)PdL](n) (n+) [a(2)=(R,R)-1,2-diaminocyclohexane (R,R-dach), (S,S)-1,2-diaminocyclohexane (S,S-dach); n=4, 6; LH=2-hydroxypyrimidine (2-Hpymo), 4,6-dimethyl-2-hydroxypyrimidine (2-Hdmpymo) and 4-hydroxypyrimidine (4-Hpymo)] were obtained by reaction of cis-[a(2)Pd(H(2)O)(2)](2+) and LH in aqueous media. The po...

The structural properties of micelles formed by the non-ionic surfactant, Triton X-114 (TX-114), were investigated using all-atom molecular dynamics (MD) simulations. Additionally, we effect solubilisation sodium salts two nonsteroidal anti-inflammatory drugs, ibuprofen and indomethacin, upon TX-114 micelles. micelle in absence drugs has an aspherical shape. We find that as continues to solubil...

Au-nanoclusters between 2 and 8 nm in diameter were deposited onto solid substrates in different pattern geometries. The basis of this approach is the self-assembly of polystyrene-b-poly[2-vinylpyridine (HAuCl4)] diblock copolymer micelles into uniform monomicellar films on solid supports such as Si-wafers or glass cover slips. HAuCl4 as metallic precursor or a single solid Au-nanoparticle caus...

Hybrid polyion complex (HPIC) micelles are nanoaggregates obtained by complexation of multivalent metal ions by double hydrophilic block copolymers (DHBC). Solutions of DHBC such as the poly(acrylic acid)-block-poly(acrylamide) (PAA-b-PAM) or poly(acrylic acid)-block-poly(2-hydroxyethylacrylate) (PAA-b-PHEA), constituted of an ionizable complexing block and a neutral stabilizing block, were mix...

Our atomistic molecular dynamics simulations reveal the existence of bound and free water molecules in the hydration layer of an aqueous micelle. The bound water molecules can be either singly or doubly hydrogen bonded to the polar head group on the surface of the micelle. The ratio of bound to free water is found to be approximately equal to 9:1 at 300 K. email:[email protected] email:bbagchi@...

The rate of release of iron to 1,10-phenanthroline from ferritin fractions of different iron contents has been studied. The experimental results could be interpreted by a simple hypothetical model of the shape of the hydrous ferric oxide micelle at different iron contents, and reasonable correlation obtained between the rate of release and the calculated micelle surface areas. Initial rates of ...

Two-dimensional Nuclear Overhauser Enhancement SpectroscopY NMR has been applied to study sodiumdodecylsulfate (SDS)/polyethyleneoxide (PEO)/D2O at 10, 20, 25, and 40 ◦C. The results indicate that PEO interacts preferentially with the surface of the micelle aggregates at 20 and 25 ◦C, displacing some water molecules from the hydration sphere. At 40 ◦C the polymer tends to penetrate the interior...