Cosmic rays are known to cause biological effects directly and through ionizing radiation produced by their secondaries. These effects have been detected in airline crews and other specific cases where members of the population are exposed to above average secondary fluxes. Recent work has found a correlation between solar particle events and congenital malformations. In this work we use the re...

Ionizing radiation interacts with biological systems to produce reactive oxygen species and reactive nitrogen species which attack various cellular components. Radio-protectors act as prophylactic agents to shield healthy cells and tissues from the harmful effects of radiation. Past research on synthetic radio-protectors has brought little success, primarily due to the various toxicity-related ...

Medical imaging procedures with x-ray, computed tomography (CT) and nuclear isotopes use ionizing radiation.1–4 On the other hand, ultrasound and magnetic resonance imaging (MRI) do not. When biological tissues are exposed to radiation, the effects are related to the type of radiation and the amount absorbed. Units of absorbed dose are grays (Gy) (joules/kilogram). One rad (radiation absorbed d...

Accidental or therapeutic total body exposure to ionizing radiation has profound pathophysiological consequences including acute radiation syndrome. Currently only investigational drugs are available in case of radiological or nuclear accidents or terrorism. Lack of selective radioprotectants for normal tissues also limits the therapeutic doses that can be delivered to treat cancers. CD47 is a ...

alzheimer’s disease, the most common type of dementia and a progressive neurode-generative disease, occurs when the nerve cells in the brain die. although there are medications that can help delay the development of alzheimer’s disease, there is cur-rently no cure for this disease. exposure to ionizing and non-ionizing radiation may cause adverse health effects such as cancer. looking at the ot...

Ionizing radiation is an important component of multimodal therapy for alveolar rhabdomyosarcoma (ARMS). We sought to evaluate the ability of IFN-beta to enhance the activity of ionizing radiation. Rh-30 and Rh-41 ARMS cells were treated with IFN-beta and ionizing radiation to assess synergistic effects in vitro and as orthotopic xenografts in CB17 severe combined immunodeficient mice. In addit...

Introduction Radiation that has sufficient energy to remove electrons from atoms is called “ionizing radiation.” Ionization results in the production of negatively charged free electrons and positively charged ionized atoms. Ionizing radiation can be classified into two groups: photons (includes X-radiation and gamma radiation) and particles (includes alpha and beta particles and neutrons). The...