β-Cell plasticity governs the adjustment of β-cell mass and function to ensure normoglycemia. The study of how β-cell mass is controlled and the identification of alternative sources of β-cells are active fields of research. β-Cell plasticity has been implicated in numerous physiological and pathological conditions. We developed a mice model in which we induced major β-cell mass atrophy by impl...

We study …rms’preferences towards intellectual property rights (IPR) regimes in a North-South context, using a simple duopoly model where a ’North’ and a ’South’ …rm compete in a third market. Unlike other contributions in this …eld, we explicitly introduce the South’s capability to undertake cost-reducing R&D, but maintain the South’s inferiority in utilizing and managing its R&D. In contrast ...

Chromatin template activity of mouse parotid glands increases after a single injection of isoproterenol (IPR), a procedure that causes, after a lag period of 20 hr, a marked stimulation of DNA synthesis and cell division in salivary glands of rodents. The increase in chromatin template activity occurs as early as 1 hr and peaks between 6 and 10 hr after IPR, paralleling previously reported chan...

The purpose of this study was to compare the epidemiology of freestyle and Greco-Roman wrestling injuries sustained during a 2006 United States (US) national tournament. A prospective injury surveillance study was conducted at the US 2006 ASICS/Vaughan Cadet and Junior National Championships. There were 83 freestyle- and 55 Greco-Roman-related injuries sustained, with the rate of injury per 100...

Complexes of the type (η(3)-allyl)Pd(L)(Cl) and (η(3)-indenyl)Pd(L)(Cl) are highly active precatalysts for the Suzuki-Miyaura reaction. Even though allyl and indenyl ligands are similar to cyclopentadienyl (Cp) ligands, there have been no detailed comparative studies exploring the activity of precatalysts of the type (η(5)-Cp)Pd(L)(Cl) for Suzuki-Miyaura reactions. Here, we compare the catalyti...

Donor(thf)-induced tetramethylaluminate cleavage of Ln(AlMe(4))(2)(NSiMe(3)Ar(iPr)) as well as the reaction of (LnMe(3))(n) (Ln = Y, Ho, Lu) with HNSiMe(3)Ar(iPr) in tetrahydrofuran affords unprecedented trinuclear rare-earth metal tetramethyl methylidene complexes which act as Schrock-type nucleophilic carbenes and methyl transfer agents.

The new well-defined catalyst [Pd(μ-Cl)Cl(IPr*)]2 enables the efficient Grignard reagent cross-coupling for the synthesis of tetra-ortho-substituted biaryls. The high reactivity of the complex is associated with the important bulkiness of the IPr* ligand. The dimer represents the most efficient catalyst reported to date for this challenging transformation.

The three-coordinate iron(II) NHC complexes [(IPr)Fe(N'')2] (1) and [(I(t)Bu)Fe(N'')2] (3) (N'' = N(SiMe3)2) react with PhSeH or LiSePh to give the iron(II) selenolates [(IPr)Fe(N'')(SePh)] (6) and [I(t)Bu(H)][(aI(t)Bu)Fe(SePh)3], [I(t)Bu(H)][7], with complex 7 containing an abnormal NHC ligand.

Treatment of anhydrous FeX2 (X = Cl, Br) with 1 equiv. of the asymmetric chiral PNP pincer ligands PNP-R,TAD (R = iPr, tBu) with an R,R-TADDOL (TAD) moiety afforded complexes of the general formula [Fe(PNP)X2]. In the solid state these complexes adopt a tetrahedral geometry with the PNP ligand coordinated in κ(2)P,N-fashion, as shown by X-ray crystallography and Mössbauer spectroscopy. Magnetiz...

Alkynes and olefins insert into [(IPr)CuH] 2 (IPr = N,N-bis-(2,6diisopropylphenyl)-1,3-imidazol-2-ylidene) to give copper vinyl and copper alkyl complexes. These copper complexes insert CO2 into the Cu-C bond to form copper acrylate and copper carboxylate complexes. Acrylic and carboxylic acids can be isolated