نتایج جستجو برای: irf

تعداد نتایج: 1944  

Journal: :Molecular and cellular biology 2000
K P Kumar K M McBride B K Weaver C Dingwall N C Reich

Viral double-stranded RNA (dsRNA) generated during the course of infection leads to the activation of a latent transcription factor, dsRNA-activated factor 1 (DRAF1). DRAF1 binds to a DNA target containing the type I interferon-stimulated response element and induces transcription of responsive genes. DRAF1 is a multimeric transcription factor containing the interferon regulatory factor 3 (IRF-...

Journal: :Infection and immunity 2008
Asha Jayakumar Michael J Donovan Vinita Tripathi Marcelo Ramalho-Ortigao Mary Ann McDowell

The salient feature of dendritic cells (DC) is the initiation of appropriate adaptive immune responses by discriminating between pathogens. Using a prototypic model of intracellular infection, we previously showed that Leishmania major parasites prime human DC for efficient interleukin-12 (IL-12) secretion. L. major infection is associated with self-limiting cutaneous disease and powerful immun...

2014
Takujiro Homma Daisuke Ishibashi Takehiro Nakagaki Takayuki Fuse Kazunori Sano Katsuya Satoh Ryuichiro Atarashi Noriyuki Nishida

As a prompt response against invasion of various viruses, interferon regulatory factor-3 (IRF-3) is initially phosphorylated to become activated and upregulates mainly Type I Interferons (IFN-I) in most cell types. We previously reported that IRF-3-dependent host innate immune responses partially interfere in infection of prions. Here, we found that stable infection of prion suppressed IRF-3 ge...

Journal: :American journal of respiratory cell and molecular biology 2010
Reena Bhandare Gautam Damera Audreesh Banerjee Jamie R Flammer Stefan Keslacy Inez Rogatsky Reynold A Panettieri Yassine Amrani Omar Tliba

Glucocorticoid (GC) insensitivity represents a profound challenge in managing patients with asthma. The mutual inhibition of transcriptional activity between GC receptor (GR) and other regulators is one of the mechanisms contributing to GC resistance in asthma. We recently reported that interferon regulatory factor (IRF)-1 is a novel transcription factor that promotes GC insensitivity in human ...

Journal: :The Journal of biological chemistry 1996
W Luo D G Skalnik

Repressor elements in the gp91(phox) promoter are necessary to restrict tissue-specific transcription to mature phagocytes. Deletion of these elements leads to significant promoter activity in cell lines such as HEL and K562 that do not normally express gp91(phox). The -100 to +12 base pair gp91(phox) promoter region is sufficient to direct maximal de-repressed transcription in these cells. How...

Journal: :The Journal of biological chemistry 1993
B R Henderson C Seiser L C Kühn

Iron regulatory factor (IRF) is a cytoplasmic RNA-binding protein involved in regulating iron homeostasis. IRF controls expression of ferritin and transferrin receptor post-transcriptionally via specific binding to stem-loop iron-responsive elements (IREs) located in the untranslated regions of the respective mRNAs. We have confirmed by RNA band-shift analysis that a second IRE-protein complex ...

2015
Ruey-Chyi Su Andrew Plesniarski Zhujun Ao Joshua Kimani Aida Sivro Walter Jaoko Frank A Plummer Xiaojian Yao Terry Blake Ball

Cells from women who are epidemiologically deemed resistant to HIV infection exhibit a 40-60% reduction in endogenous IRF-1 (interferon regulatory factor-1), an essential regulator of host antiviral immunity and the early HIV replication. This study examined the functional consequences of reducing endogenous IRF-1 on HIV-1 replication and immune response to HIV in natural HIV target cells. IRF-...

1999
Masatsugu Horiuchi Hiroyuki Yamada Masahiro Akishita Masaaki Ito Kouichi Tamura Victor J. Dzau

Apoptosis has been reported to play a pivotal role in vascular remodeling. However, cellular mechanisms of apoptosis in vascular smooth muscle cells (VSMCs) have not been well defined. In this study, we focused on interleukin-1b–converting enzyme (ICE), a key protease in the induction of apoptosis in lymphocytes and fibroblasts. We observed an increase in ICE mRNA expression in rat aortic VSMCs...

Journal: :Infection and immunity 2002
Jinkyung Ko Annette Gendron-Fitzpatrick Thomas A Ficht Gary A Splitter

Interferon regulatory factor 1-deficient (IRF-1(-/-)) mice infected with virulent Brucella abortus 2308 at 5 x 10(5) CFU developed acute hepatitis similar to many natural hosts but, unlike natural hosts, IRF-1(-/-) mice were unable to resolve infection and died. In contrast, IRF-1(-/-) mice survived when infected at 5 x 10(5) CFU with several attenuated Brucella strains (S19, RB51, cbp, and cyd...

2013
Daisy Machado Silvia M. Shishido Karla C. S. Queiroz Diogo N. Oliveira Ana L. C. Faria Rodrigo R. Catharino C. Arnold Spek Carmen V. Ferreira

Melanoma is one of the most aggressive skin cancers due to its high capacity to metastasize. Treatment of metastatic melanomas is challenging for clinicians, as most therapeutic agents have failed to demonstrate improved survival. Thus, new candidates with antimetastatic activity are much needed. Riboavin (RF) is a component of the vitamin B complex and a potent photosensitizer. Previously, our...

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