The involvement of metal in oxidation and coupled phosphorylation by cell-free preparations of Mycobacterium phlei was examined. The oxidation of succinate was inhibited by metal-chelating agents, but with /3-hydroxybutyrate, chelating agents exhibited an uncoupling effect. The site of inhibition was found to be between the flavoprotein and the cytochrome b regions of the electron transport cha...

Iron is one of the most widespread elements in the earth crust. Its presence in soils has long been a forgone pedological fact. Iron toxicity occurs when, under the reductive effect of the environment, bacteria cause anaerobic respiration by releasing large quantities of ferrous ions (Fe2+) in the solution. The objective of this paper is to present an overview of the iron poisoning, etiology, p...

OBJECTIVE This retrospective study evaluated iron chelating therapy (ICT) discontinuation and costs in Sickle cell disease (SCD) Medicaid recipients using healthcare claims from 2006-2010. METHODS Patients with ≥1 SCD diagnosis claim, ≥2 claims for deferoxamine (DFO) or deferosirox (DFX), and continuous enrollment ≥6 months prior to and 18 months following ICT initiation were included. Outcom...

Iron chelation therapy is used to reduce iron overload development due to its deposition in various organs such as liver and heart after regular transfusion. In this review, different iron chelators implicated in treatment of iron overload in various clinical conditions have been evaluated using more up-to-date studies focusing on these therapeutic agents. Deferoxamine, Deferiprone and Deferasi...

In the last decade, significant advances have been made in the treatment of patients with Myelodysplastic Syndromes (MDS). Although best supportive care continues to have an important role in the management of MDS, to date the therapeutic approach is diversified according to the IPSS risk group, karyotype, patient's age, comorbidities, and compliance. Hematopoietic growth factors play a major r...

The antioxidant effects of meat fractions from chicken breast and beef loin were compared. Five meat fractions - homogenate (H), precipitate (P), supernatant (S), high-molecular-weight (HMW) and low-molecular-weight (LMW) fractions - were prepared from chicken breast or beef loin. Each of the fractions were added to a phospholipid liposome model system containing catalysts (metmyoglobin, ferrou...

Barium sulfate (barite) is one of the widely used weighting materials in the preparation of drilling fluid for deep oil and gas wells. Barite is not soluble in the regular solvents; such as, hydrochloric acid (HCl) and other acids. Therefore, in this study, we focused on evaluating the dissolution of the industrial barite particles in different chelating agents. Chelating agents; such as, dieth...

Regular red cell transfusion therapy ameliorates disease-related morbidity and can be lifesaving in patients with various hematological disorders. Transfusion therapy, however, causes progressive iron loading, which, if untreated, results in endocrinopathies, cardiac arrhythmias and congestive heart failure, hepatic fibrosis, and premature death. Iron chelation therapy is used to prevent iron l...

The investigation of chelating agents with potential therapeutic value in patients with transfusional iron overload has been facilitated by the use of Chang cell cultures. These cells have been incubated with [59Fe]transferrin for 22 hr, following which most of the intracellular radioiron is found in the cytosol, distributed between a ferritin and a nonferritin form. Iron release from the cells...