Our aim is to summarize and discuss the recent literature linking diabetes mellitus with heart failure, and to address the issue of the optimal treatment for diabetic patients with heart failure. THE STUDIES LINKING DIABETES MELLITUS (DM) WITH HEART FAILURE (HF) : The prevalence of diabetes mellitus in heart failure populations is close to 20% compared with 4 to 6% in control populations. Epide...

INTRODUCTION We recently identified a set of plasma microRNAs (miRNAs) that are downregulated in patients with heart failure in comparison with control subjects. To better understand their meaning and function, we sought to validate these circulating miRNAs in 3 different well-established rat and mouse heart failure models, and correlated the miRNAs to parameters of cardiac function. METHODS ...

Senescence and death of primitive cells and myocytes lead to premature cardiac aging and heart failure – C. Chimenti and others Age-dependent impairment of angiogenesis – A. Rivard and others Age and outcome with contemporary thrombolytic therapy. Results from the GUSTO-1 trial – H. D. White and others Age-related increase in mortality among patients with first myocardial infarctions treated wi...

After initial reports of successful stem cell delivery to the injured heart, the clinical feasibility and safety of this new therapeutic strategy has been established, thereby focusing on the treatment of ischemic heart disease. Over 3000 patients with either recent myocardial infarction or chronic ischemic heart failure have been treated so far by means of interventional cardiology and cardiac...

Heart failure patients may have impaired cerebral autoregulation and regional blood flow abnormalities. Predisposition to thromboembolic complications occur because of dilated chambers abnormal flow, vessel/chamber lining particles in heart patients. Epidemiological clinical studies document an increased rate failure. Well known/accepted indications oral anticoagulation therapy prevent events a...

I have read the article entitled “Is cardiac resynchronisation therapy feasible, safe and beneficial in the very elderly?” by Olechowski, et al. with great interest, recently published in Journal of Geriatric Cardiology. The investigators reported that implantation of cardiac resynchronisation therapy (CRT) is feasible and safe in very elderly despite extensive co-morbidity. I would like to emp...