نتایج جستجو برای: ischemic kidney injury

تعداد نتایج: 573979  

Journal: :Journal of the American Society of Nephrology 1999

Journal: :American journal of physiology. Renal physiology 2015
Pinelopi P Kapitsinou Volker H Haase

More effective therapeutic strategies for the prevention and treatment of acute kidney injury (AKI) are needed to improve the high morbidity and mortality associated with this frequently encountered clinical condition. Ischemic and/or hypoxic preconditioning attenuates susceptibility to ischemic injury, which results from both oxygen and nutrient deprivation and accounts for most cases of AKI. ...

Journal: :Journal of the American Society of Nephrology : JASN 2017
Amy McCurley Stella Alimperti Silvia B Campos-Bilderback Ruben M Sandoval Jenna E Calvino Taylor L Reynolds Catherine Quigley Joshua W Mugford William J Polacheck Ivan G Gomez Jennifer Dovey Graham Marsh Angela Huang Fang Qian Paul H Weinreb Brian M Dolinski Shaun Moore Jeremy S Duffield Christopher S Chen Bruce A Molitoris Shelia M Violette Michael A Crackower

Ischemia-reperfusion injury (IRI) is a leading cause of AKI. This common clinical complication lacks effective therapies and can lead to the development of CKD. The αvβ5 integrin may have an important role in acute injury, including septic shock and acute lung injury. To examine its function in AKI, we utilized a specific function-blocking antibody to inhibit αvβ5 in a rat model of renal IRI. P...

Journal: :Journal of the American Society of Nephrology 2009

Journal: :Journal of the American Society of Nephrology 2012

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