OBJECTIVE The elevated plasma glucose level and/or insulin resistance in diabetes or impaired glucose tolerance play important roles in the pathogenesis of arterial stiffness. The present study investigated whether insulin resistance correlated with arterial stiffness before the development of glucose intolerance. METHODS We conducted a cross-sectional analysis in 872 young to middle-age indi...

The ISI subject categories classify journals included in the Science Citation Index (SCI). The aggregated journal-journal citation matrix contained in the Journal Citation Reports can be aggregated on the basis of these categories. This leads to an asymmetrical transaction matrix (citing versus cited) which is much more densely populated than the underlying matrix at the journal level. Explorat...

AIMS/INTRODUCTION The present study was designed to investigate the correlations between the serum testosterone level and insulin sensitivity in elderly male type 2 diabetes patients with osteoporosis. MATERIALS AND METHODS A total of 35 elderly male patients with type 2 diabetes (type 2 diabetes group), 30 elderly male type 2 diabetes patients combined with osteoporosis (DO group) and 30 hea...

PURPOSE Patients with neurological conditions often experience severe debilitating lower urinary and bowel dysfunction in addition to the physical disabilities. However, only the bladder has received the attention of medical providers with neurogenic bowel being poorly understood and characterized. MATERIALS AND METHODS This is a cross-sectional analysis of a prospective institutional neuroge...

BACKGROUND Non-alcoholic fatty liver disease (NAFLD) is an independent predictor of type 2 diabetes mellitus (T2DM). Insulin resistance and beta-cell dysfunction are involved in the pathogenesis of T2DM. Insulin resistance is associated with NAFLD but little is known about beta-cell dysfunction and NAFLD. AIM We tested whether NAFLD severity is associated with insulin sensitivity and beta-cel...

OBJECTIVE The studies that have extensively evaluated the relation between adipokines and metabolic parameters in acromegaly treatment are quite discordant. We aimed to evaluate and correlate a set of selected adipokines, known to have a metabolic role, with the disease activity, metabolic status and treatment modalities. DESIGN Data of 56 consecutive acromegalic patients (31 M and 25 F; aged...

For the assessment of glucose tolerance from IVGTT data in Zucker rat, minimal model methodology is reliable but time- and money-consuming. This study aimed to validate for the first time in Zucker rat, simple surrogate indexes of insulin sensitivity and secretion against the glucose-minimal-model insulin sensitivity index (SI) and against first- (Φ1) and second-phase (Φ2) β-cell responsiveness...

Purpose: To investigate associations between computer use data and sleep quality among university students. Materials and Methods: This descriptive, cross-sectional study was performed on 312 students of Tehran University of Medical Sciences, Iran. Data was collected using Epworth Sleepiness Scale (ESS), Insomnia Severity Index (TSI), Pittsburgh Sleep Quality Index (PSQI), and a background...

OBJECTIVE Glucolipotoxicity is a major pathophysiological mechanism in the development of insulin resistance and type 2 diabetes mellitus (T2D). We aimed to detect subtle changes in the circulating lipid profile by shotgun lipidomics analyses and to associate them with four different insulin sensitivity indices. METHODS The cross-sectional study comprised 90 men with a broad range of insulin ...