Multiple forms of liver microsomal cytochrome P-450 isolated from immature male rats pretreated with phenobarbital or 3-methylcholanthrene are described. A fraction. of low specific content (Fraction A, 1.7 to 4.0 nmol of cytochrome P-450 per mg of protein) and a fraction substantially purified (Fraction B, 9.0 to 11.0 mnol of cytochrome P-450 per mg of protein) are obtained by DEAE-cellulose c...

Treatment of pregnant rats with as little as 0.5 mg of BP per kg p.o. for 3 days stimulated the metabolism of the hydrocarbon by maternal liver and placenta, while a 20-fold higher dose of this hydrocarbon was necessary for stimulation of BP hydroxylation in fetal liver. BP metabolism was increased in fetal and maternal liver microsomes after treatment of pregnant rats with 3-methylcholanthrene...

The potential of continuous flow technology to streamline the synthesis, purification and postmodification reactions isocyanides is reported.

A new iron complex with a thioamide SNS pincer type ligand, [FeBr2(κ(3)-H2L(DPM))] (κ(3)-H2L(DPM) = 2,6-bis(N-2,6-bis(diphenylmethyl)-4-isopropylphenylthioamide)pyridine), was synthesized. This complex reacts with NaH in THF to yield a unique Fe(ii) complex with two THF molecules, [Fe(THF)2(κ(3)-L(DPM))] (κ(3)-L(DPM) = 2,6-bis(N-2,6-bis(diphenylmethyl)-4-isopropylphenyliminothiolate)pyridine). ...

The pathways for the spontaneous self-assembly of one-dimensional oligomeric chains from the adsorption of 1,4-phenylene diisocyanide (PDI) on Au(111) surface are explored using density functional theory. It has been shown previously that the chain comprises repeating −(Au−PDI)− structures. The results show that the chains form from mobile Au−PDI adatom complexes and that chains propagate by th...

Treatment of pregnant rats with as little as 0.5 mg of BP per kg p.o. for 3 days stimulated the metabolism of the hydrocarbon by maternal liver and placenta, while a 20-fold higher dose of this hydrocarbon was necessary for stimulation of BP hydroxylation in fetal liver. BP metabolism was increased in fetal and maternal liver microsomes after treatment of pregnant rats with 3-methylcholanthrene...

Aims. Following the first detection of hydrogen isocyanide (HNC) in Titan’s atmosphere, we have devised a new neutral chemical scheme for hydrogen cyanide (HCN) and HNC in the upper atmosphere of Titan. Methods. Our updated chemical scheme contains 137 compounds (with C, H, O and N elements) and 788 reactions (including 91 photolysis processes). To improve the chemistry of HNC and HCN, a carefu...