Three experiments were conducted to characterize the metabolism of isoflavones from soy milk in women: two meals in 2 wk separated by a 1-wk washout period (Experiment 1), one meal feeding (Experiment 2) and six consecutive days of feeding (Experiment 3). Urine and plasma samples were extracted directly or predigested before extraction with H-2 beta-glucuronidase/sulfatase or B-3 beta-glucuroni...

Soybeans and soy-based products contain isoflavones which can be used for nutraceutical medical applications. In soybeans in unfermented soy foods, are normally present as glycosides. Isoflavone glycosides enzymatically converted to isoflavone aglycones, thus releasing the sugar molecule. The effective absorption of humans requires bioconversion aglycones through activity enzyme β-glucosidase. ...

Chemically, soy contains a group of phytoestrogens called isoflavones, predominantly genistein and daidzein. The aim of the present study was to determine the effects of post weaning consumption of dietary soy isoflavones on prepubertal and postpubertal serum levels of some reproductive hormones of male Wistar rats. The study involved investigating the effects of different doses of isoflavones ...

Endothelial dysfunction is widely considered as a prognostic marker of future cardiovascular events in clinical settings, even in patients who do not have untoward symptoms of cardiovascular disease. Thus, treatments aimed at restoring endothelial dysfunction have important implications Many studies have demonstrated that supplementary treatments can improve endothelial function. These favourab...

BACKGROUND In the literature, supplement of soy aglycons of isoflavone as estrogen agonists in improvement of serum biochemical attributes, liver antioxidative capacities and vaginal epithelium protection has been meagerly investigated. In this study, ovariectomized (OVX) rats were used as an animal model to simulate post-menopausal status. Supplementary health benefits of soy aglycons of isofl...

The first example of non-symmetric isoflavone-based fast photo-switchable liquid crystals with different functional groups at the terminal position were synthesized and characterized. Polarizing optical microscopy study revealed that the compounds showed least ordered nematic phase. Optical photo switching study exhibited very fast photoisomerization effect in solution. The E-Z and Z-E conversi...

Chemical treatment of diabetes mellitus is widely studied and controlling of blood glucose level is the main course of therapy. In type 2 diabetes mellitus, insulin resistance is the major problem. An isoflavone C-glucoside, puerarin (1), is known to enhance glucose uptake into the insulin sensitive cell and is thought to be a candidate for treatment of diabetes mellitus. We synthesized 1 and s...

Isoflavone, Biochanin A, Dihydrobiochanin A, Phenylacetic acids, Fusarium javanicum After a lag-phase of 1 h a mycelial suspension of Fusarium javanicum completely degraded 5,7-dihydroxy-4'-methoxyisoflavone (biochanin A) to a series of transiently accumulating catabolites. The compounds were elucidated by spectroscopic techniques and are arranged in the first known degradative pathway for an i...

A carpin (3-hydroxy-9-methoxypterocarpan) (Medicarpin) (1) and four isoflavones, 7-hydroxy-4'-methoxy-isoflavone (Formononetin) (2); 7,4'-dimethoxyisoflavone (3); 5,4'-dihydroxy-7-methoxy-isoflavone (Prunetin) (4) and 7-hydroxy-6,4'-dimethoxyisoflavone (5) were isolated from the tuber roots of Butea superba Roxb. Compounds 2 and 4 showed moderate cytotoxic activity on KB cell lines with IC(50) ...

A new isoflavone (1) isolated from the roots of Flemingia strobilifera (L) R. Br. was identified as 5,7,4'-trihydroxy 8,2',5'-tri(3-methylbut-2-enyl)isoflavone along with the known phytoconstituents: 5,7,2',4'-tetrahydroxyisoflavone (2), 5,7,4'-trihydroxyisoflavone (3) and beta-sitosterol (4). Structure assignments were performed on the basis of spectroscopic data including homo- and heteronucl...