PurposeAlternative ribonucleic acid (RNA) transcript splicing produces multiple RNA isoforms from the same gene which are associated with many heart diseases. However, little is known about alternative events in donor hearts during cold preservation.MethodsWe examined transcriptomic profile of left ventricle human comparing 0 and 8 hours preservation histidine-tryptophan-ketoglutarate solution....

Abstract Prostate cancer (PCa) is a highly heterogeneous and unpredictable progressive disease. Sensitivity of PCa cells to androgens play central role in tumor aggressiveness but biomarkers with high sensitivity specificity that follow the progression disease has not yet been verified. The vitamin D endocrine system its receptors, Vitamin Receptor (VDR) Protein Disulfide-Isomerase A3 (PDIA3), ...

Millions of people are affected by excessive fluoride intake. The effect fluorides on the activation or inhibition redox-sensitive transcription factors remains poorly understood. aim this research is to examine factor AP-1 changes in activity inducible NO synthase and constitutive isoforms synthase, concentrations peroxynitrites alkali alkaline earth metals, nitrites nitrosothiols gastric muco...

A variety of isoforms of mammalian voltage-gated sodium channels have been described. Ten genes encoding sodium channel alpha subunits have been identified, and nine of those isoforms have been functionally expressed in exogenous systems. The alpha subunit is associated with accessory beta subunits in some tissues, and three genes encoding different beta subunits have been identified. The alpha...

In this short review, I will focus on how a unique tau gene may produce many tau isoforms through alternative splicing and how the phosphorylation of these isoforms by different kinases may affect their activity and behaviour. Indeed, each of the different tau isoforms may play a distinct role under both physiological and pathological conditions. Thus, I will discuss whether a tau code exists t...

Methodology combining mass spectrometry imaging (MSI) with ion mobility separation (IMS) has emerged as a biological technique due to its versatility, sensitivity and label-free approach. This been shown separate isomeric compounds such lipids, amino acids, carboxylic acids carbohydrates. report describes in combination traveling-wave matrix-assisted laser desorption/ionization (MALDI). Positiv...