histone deacetylase inhibitors have gained a great deal of attention recently for the treatment of cancers and inflammatory diseases. so design of new inhibitors is of great importance in pharmaceutical industries and labs. creating pharmacophor models in order to design new molecules or search a library for finding lead compounds is of great interest. this approach reduces the overall cost ass...

a new series of alkylthio imidazole analogues of captopril, an ace inhibitor used in the treatment of hypertension, was designed and synthesized in order to obtain agents more active than captopril with less side effects. all the compounds thus prepared were purified and characterized by ir, nmr and mass analytical instruments.

objective: alpha-synuclein is a major component of protein plaques in synucleinopathies, particularly parkinson’s disease. the purpose of this study is to assess the inhibitory effects of cuminaldehyde on the fibrillation of alpha-synuclein. methods: alpha-synuclein was expressed in escherichia coli and subsequently purified. for the process of fibrillation, purified protein was incubated at 3...

factors such as oxidative stress and reduced acetylcholine level have been implicated in alzheimer’s disease (ad) pathology and recently there has been a trend towards natural product research to find potential sources of antioxidants and acetylcholinesterase inhibitors in the plants kingdom. centaurea is a genus with about 500 species world wild, many of them have shown to possess biologic act...

Understanding the genetic networks that operate inside cells will require the dissection of interactions among network members. Here we describe a peptide aptamer isolated from a combinatorial library that distinguishes among such interactions. This aptamer binds to cyclin-dependent kinase 2 (Cdk2) and inhibits its kinase activity. In contrast to naturally occurring inhibitors, such as p21(Cip1...

OBJECTIVES Bacterial enoyl-ACP reductase (FabI) has been validated as a novel antibacterial target for tackling infections caused by multidrug-resistant pathogens. A few FabI inhibitors, however, are known. This study isolated a new FabI inhibitor from Penicillium sp. METHODS A screening programme led to the selection of a Penicillium sp. producing a strong FabI-inhibitory metabolite. The che...

• Detection of bleomycin-induced DNA damage in patient cells using a single molecule imaging assay is demonstrated. The detects an inter-individual variation and repair. can detect deficiency repair caused by pathway inhibitor. potential tool for personalized treatment patients undergoing chemotherapy. Quantification the induced chemotherapy may aid personalization dose used. However, assays to...

inhibitor development is a lifelong challenge for patients with bleeding disorders who received replacement therapy. most commonly, inhibitor formation was observed in hemophilia a patients but patients with rare bleeding disorders (rbd) especially patients with deficiency of factor xiii (fxiii) and factor v (fv) can develop an inhibitor against exogenous factors. several factors considered as ...

The protective effect of the aqueous extracts of Santolina pectinata (Lag.) aerial parts (Odorized aqueous extract (AE1) and Deodorized aqueous extract (AE2)) on the corrosion of mild steel (MS) in 1M HCl solution were tested by the weight loss (WL) analysis, potentiodynamic polarization (PDP) and electrochemical impedance spectroscopy (EIS) methods. The inhibition efficiency (%IE) is highly ra...

Visceral angioedema is a rare complication of therapy with angiotensin-converting enzyme (ACE) inhibitors. Clinical presentation includes nausea, vomiting, abdominal pain and diarrhea. Early detection of this entity can prevent recurrent episodes and unnecessary invasive procedures, including surgery. This article describes a 46-year-old-woman who presented to the emergency department with abdo...