Intraventricular hemorrhage (IVH) is a neurological urgency with a high mortality and unfavorable prognosis. Fast removal of intraventricular blood should be considered as a priority. The current treatments of IVH mainly focus on external ventricular drain and endoscopic aspiration, but neither way can remove the blood in the fourth ventricle easily and relieve the compression of brainstem. Her...

BACKGROUND Acute transient obstructive hydrocephalus is rare in adults. We describe a patient with intraventricular hemorrhage (IVH) who experienced the delayed development of acute transient hydrocephalus. CASE REPORT A 33-year-old man with a previously diagnosed Spetzler-Martin Grade 5 arteriovenous malformation presented with severe headache, which was found to be due to IVH. Forty hours a...

Germinal matrix-intraventricular haemorrhage (GMH-IVH) remains a serious problem in the very and extremely preterm infant. This article reviews current methods of diagnosis, treatment and neurodevelopmental outcome in preterm infants with low-grade and severe GMH-IVH. We conclude that there is still no consensus on timing of intervention and treatment of infants with GMH-IVH, whether or not com...

OBJECTIVE To study the efficacy and complications of low dose indomethacin in the reduction of major intraventricular hemorrhage (IVH) in very low birth weight (VLBW) babies. DESIGN prospective randomized controlled trial (interim analysis) SETTING Level III neonatal intensive care unit of a perinatal tertiary care center. PATIENTS Newborn babies with birth weights between 750-1250 g were...

Given that a trend towards an increase in overall IVH incidence with natural surfactant was noted in the metaanalysis by Soll,2 an important question arises: Could a recent trend in higher concentrations/doses of natural surfactant lead to an increase in IVH? It is not suggested that there is a consistent association between surfactant treatment and IVH, but this is an interesting consideration...

Administration of antenatal corticosteroids to pregnant women with imminent delivery of a newborn at 24 to 34 weeks of gestation represents one of the most important advances in perinatal medicine in the past 25 years1,2. A single course of antenatal steroid has been associated with a decrease in acute neonatal systemic morbidity and mortality after preterm birth reducing the risk of respirator...

BACKGROUND Mean platelet volume [MPV] is an important predictor for many diseases and larger platelets are more reactive and associated with shortened bleeding time. Although elevated MPV values are related to respiratory distress syndrome [RDS] in neonates, there are, to our knowledge, no data investigating the relationship between MPV and other diseases of preterm infants. AIM To assess the...

AIM We aimed to identify specific polymorphisms of genes encoding for vascular endothelial growth factor A (VEGFA), endothelial nitric oxide synthase (eNOS), renin-angiotensin system (angiotensinogen gene [AGT], angiotensinogen type 1 receptor [AGTR1], angiotensin-converting enzyme [ACE]), and heme oxygenase-1 (HMOX-1) in a cohort of preterm infants and correlate their presence with the develop...

Intraventricular hemorrhage (IVH) is a common disease among preterm infants with an occurrence of 12-20% in those born at less than 35 weeks gestational age. Neonates at risk of IVH are monitored by conventional 2D ultrasound (US) for hemorrhage and potential ventricular dilation. Compared to 2D US relying on linear measurements from a single slice and visually estimates to determine ventricula...