Coiled-coils are widespread protein-protein interaction motifs typified by the heptad repeat (abcdefg)(n) in which "a" and "d" positions are hydrophobic residues. Although identification of likely coiled-coil sequences is robust, prediction of strand order remains elusive. We present the X-ray crystal structure of a short form (residues 583-611), "Q1-short," of the coiled-coil assembly specific...

Trends in the labor market, as a result of global economic recession, are characterized by reduction of manpower activity, decreased number of employed and increased number of unemployed persons. As the result of economic recession more then million workplaces are expected to be lost in the European Union. The aim of this study was to analyze the influence of economic recession on labor market ...

OBJECTIVE To analyze access to and utilization of dental care services in Brazil. METHODS We used data from the 2003 and 2008 Brazilian National Household Surveys, which we compared to data from the 1998 survey. We investigated access and utilization variables at ages three, six, nine, 12, 15, and 19 years in the first (Q1) and fifth (Q5) quintiles of per capita family income. All analyses to...

A complementary DNA encoding DNA-dependent ATPase Q1 possessing DNA helicase activity, which is the major DNA-dependent ATPase in human cell extracts, was cloned from a cDNA library of human KB cells. The predicted amino acid sequence has seven consecutive motifs conserved in the RNA and DNA helicase super family and DNA helicase Q1 belongs to DEXH helicase family. A homology search indicated t...

In this paper we consider the fully nonlinear parabolic free boundary problem { F (Du)− ∂tu = 1 a.e. in Q1 ∩ Ω |Du|+ |∂tu| ≤ K a.e. in Q1 \ Ω, where K > 0 is a positive constant, and Ω is an (unknown) open set. Our main result is the optimal regularity for solutions to this problem: namely, we prove that W 2,n x ∩W 1,n t solutions are locally C 1,1 x ∩C 0,1 t inside Q1. A key starting point for...

Let u = u(q) satisfy a hyperbolic equation with impulsive input: ∂ t u(x, t)−4u(x, t) + q(x)u(x, t) = δ(x1)δ(t) and let u|t<0 = 0. Then we consider an inverse problem of determining q(x), x ∈ Ω from data u(q)|ST and (∂u(q)/∂ν) |ST . Here Ω ⊂ {(x1, . . . , xn) ∈ R|x1 > 0}, n ≥ 2, is a bounded domain, ST = {(x, t); x ∈ ∂Ω, x1 < t < T + x1}, ν = ν(x) is the unit outward normal vector to ∂Ω at x ∈ ...