BACKGROUND Disrupted circadian coordination accelerates malignant growth, but the molecular mechanism is unclear. METHODS Healthy or Glasgow osteosarcoma-bearing mice (n = 162) were synchronized with light and darkness over 2-3 weeks, submitted to an 8-hour advance onset of light every 2 days (chronic jet lag) to disrupt circadian coordination, or submitted to chronic jet lag and meal timing ...

Daily rhythms in mammals are controlled by the circadian system, which is a collection of biological clocks regulated by a central pacemaker within the suprachiasmatic nucleus (SCN) of the anterior hypothalamus. Changes in SCN function have pronounced consequences for behaviour and physiology; however, few studies have examined whether individual differences in circadian behaviour reflect chang...

The molecular basis of circadian clocks is highly evolutionarily conserved and has been best characterized in Drosophila and mouse. Analysis of the Acyrthosiphon pisum genome revealed the presence of orthologs of the following genes constituting the core of the circadian clock in Drosophila: period (per), timeless (tim), Clock, cycle, vrille, and Pdp1. However, the presence in A. pisum of ortho...

STUDY OBJECTIVES To develop a practical pre-eastward flight treatment to advance circadian rhythms as much as possible but not misalign them with sleep. DESIGN One group had their sleep schedule advanced by 1 hour per day and another by 2 hours per day. SETTING Baseline at home, treatment in lab. PARTICIPANTS Young healthy adults (11 men, 15 women) between the ages of 22 and 36 years. I...

Our understanding of the mechanisms by which sleep deteriorates with age almost exclusively stems from comparisons of young and elderly subjects. The present study investigated the different effects of a 25-h sleep deprivation on the recovery sleep initiated in the morning (when circadian sleep propensity decreases) of young (20–39 y) and middle-aged subjects (40–60 y). Middle-aged subjects sho...

the first WMFFC outside of Europe. As a private practice physician, leaving the office for a little more than ten days was no easy task. Over the past two years, however, I had been playing soccer as part of a rehabilitation plan for a knee injury I suffered several years earlier; and the WMFFC came at a perfect time for me in my recovery. So I seized the opportunity and survived the attendant ...