نتایج جستجو برای: kashan erg
تعداد نتایج: 8520 فیلتر نتایج به سال:
Osteopontin (OPN) is an extracellular matrix glycophosphoprotein that plays a key role in the metastasis of a wide variety of cancers. The high level of OPN expression in prostate cells is associated with malignancy and reduced survival of the patient. Recent studies on prostate cancer (PCa) tissue have revealed recurrent genomic rearrangements involving the fusion of the 5' untranslated region...
Recently, ETS-related gene (ERG) gene rearrangements, phosphatase tensin homologue (PTEN) deletions and EGFR family aberrations were characterized as potential biomarkers for prostate cancer (PCa) patient management. Although ERG gene rearrangement has been identified in approximately 50% of localized prostate cancers in western countries, the prognostic significance of this critical molecular ...
Osteopontin (OPN) is an extracellular matrix glycophosphoprotein that plays a key role in the metastasis of a wide variety of cancers. The high level of OPN expression in prostate cells is associated with malignancy and reduced survival of the patient. Recent studies on prostate cancer (PCa) tissue have revealed recurrent genomic rearrangements involving the fusion of the 50 untranslated region...
PURPOSE We aimed to analyze whether ERG rearrangement in biopsies could be used to assess subsequent cancer diagnosis in high-grade prostatic intraepithelial neoplasia (HGPIN) and the risk of lymph node metastasis in early prostate cancer. EXPERIMENTAL DESIGN Samples from 523 patients (361 with early prostate cancer and 162 with HGPIN) were collected prospectively. On the basis of the cutoff ...
BACKGROUND There is limited evidence that supports etiologically distinct molecular subtypes of prostate cancer, the identification of which may improve prevention. Given their antioxidant properties, we hypothesized that lycopene and tomato sauce may be especially protective against diseases harboring the common gene fusion transmembrane protease, serine 2 (TMPRSS2):v-ets avian erythroblastosi...
هدف : هدف از این پایان نامه بررسی تغییرات الکترورتینوگرام در بیماران مبتلا به گلوکوم است . زیرا گلوکوم بیماری است که اگر دیر تشخیص داده شود یا درمان نشود منجر به کوری می شود . روش مطالعه : این مطالعه یک مطالعه مشاهده ای – توصیفی – تحلیلی – مقطعی طراحی شده که نمونه شامل 25 فرد مبتلا به گلوکوم و 25 فرد سالم بوده است نمونه ها بصورت تصادفی ساده از بین مراجعین به بیمارستان های آموزشی دانشگاه آزا...
بررسی کارائی سلول های استوانه ای شبکیه در افراد مبتلا به retinitis pigmentosa به روش الکترورتینوگرام
هدف: این مطالعه به منظور بررسی کارائی سلول های استوانه ای شبکیه در افراد مبتلا به retinitis pigmentosa به روش الکترورتینوگرام (erg) انجام شده است. روش مطالعه: در این مطالعه مقطعی تحلیلی، 50 فرد مراجعه کننده به کلینیک قدس در سال 1392 وارد مطالعه شدند که شامل 25 نفر بیمار مبتلا به رتینیت پیگمنتوزا بعنوان گروه مورد و 25 فرد سالم، بعنوان گروه شاهد بودند. دو گروه تحت الکترورتینوگرام قرار گرفتند و و...
Over the last few years, the ETS transcription factor ERG has emerged as a major regulator of endothelial function. Multiple studies have shown that ERG plays a crucial role in promoting angiogenesis and vascular stability during development and after birth. In the mature vasculature ERG also functions to maintain endothelial homeostasis, by transactivating genes involved in key endothelial fun...
Translocations fusing the strong androgen-responsive gene, TMPRSS2, with ERG or other oncogenic ETS factors may facilitate prostate cancer development. Here, we studied 18 advanced prostate cancers for ETS factor alterations, using reverse transcription-PCR and DNA and RNA array technologies, and identified putative ERG downstream gene targets from the microarray data of 410 prostate samples. O...
Blood vessel stability is essential for embryonic development; in the adult, many diseases are associated with loss of vascular integrity. The ETS transcription factor ERG drives expression of VE-cadherin and controls junctional integrity. We show that constitutive endothelial deletion of ERG (Erg(cEC-KO)) in mice causes embryonic lethality with vascular defects. Inducible endothelial deletion ...
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