Abstract A rare genetical autosomal recessive disorder called Wilson disease (WD) is characterized by excess copper being deposited in numerous major organs, mainly the liver and brain causing hepatic, neurological mental symptoms. WD caused mutations gene ATP7B. Although not always present, Kayser-Fleischer (KF) ring pathognomonic indication of deposition corneas eyes. The condition worsens wi...

Yapıta İçkinlik (Werkimmanenz) adı verilen edebiyat kuramı, 20. yüzyılın ilk yarısında özellikle Orta Avrupa’da çok popülerdi. Emil Staiger ve Wolfgang Kayser, İçkinliğin en önemli temsilcileridir. Onlar, yaygın olan bu yorumlama biçimine sistemli bir kuram temeli kazandırmışlardır. Aynı zamanlarda ortaya çıkan benzer biçimde işleyen Yeni Eleştiri (New Criticism) kuramına, Anglo-Sakson karşılığ...

OBJECTIVE To describe the neurological manifestations, results of investigations and response to treatment in Wilson disease in children from Multan. METHODS This cross sectional study was conducted at Neurology Department of Children Hospital and Institute of Child Health Multan from June 2005 to May 2008. Fifty children were included in this study. Age at onset of symptoms, sex, duration of...

Results Since 2006, 281 patients (1-73 year old) were included in the Wilson France database (sex ratio: 1). Mean age at diagnosis was 19 years. First symptoms were neurological for 36% of the patients, hepatic for 38%, renal, psychiatric or hematologic for 11%. Fifteen percent were diagnosed after familial screening. At time of diagnosis, Kayser-Fleischer ring was observed in 95% of patients w...

Wilson's disease is an autosomal recessive disorder caused by more than 500 mutations in ATP7B gene presenting considerably clinical manifestations heterogeneity even in patients with a particular mutation. Previous findings suggested a potential role of additional genetic modifiers and environment factors on phenotypic expression among the affected patients. We conducted clinical and genetic i...

Abstract Patients suffering from Wilson’s disease accumulate copper in their body. Copper load may become visible as Kayser-Fleischer (KF) rings - colorful copper-sulfur granules the base of cornea. Reoccurrence KF patients under anti-copper medication be a sign for ineffective treatment. This work proposes hand-held sensing system based on infrared reflectivity measurement cornea potential met...

Emily S. Birkholz, MD, Thomas A. Oetting, MS, MD July 28, 2009 Chief Complaint: Referral for evaluation of Kayser-Fleischer Rings History of Present Illness: The patient was a 25 year old male who had been experiencing a right-sided subcostal tenderness and increasing fatigue for the last several months. He also had noticed dark urine, jaundice and a 60 pound weight loss. The patient was admitt...

BACKGROUND Fleischer's ring is considered to be a characteristic of keratoconus, but we have seen a ring similar to Fleischer's ring in patients with secondary keratoconus, in which the cornea becomes thinner secondarily for undetermined reasons. CASES We report 6 cases of secondary keratoconus with a corneal epithelial ring similar to the Fleischer's ring pattern. OBSERVATIONS In these 6 c...

The hyperspectral satellite EnMAP (Environmental Mapping and Analysis Program) is scheduled to launch in 2014. It is a joint project by the GFZ (Deutsches GeoForschungsZentrum), the DLR (German Aerospace Center), Kayser-Threde and OHB-System. Apart from the project management, the DLR is responsible for the development of the ground segment for EnMAP. One of the key steps of the developed proce...