نتایج جستجو برای: kcne2 gene
تعداد نتایج: 1141429 فیلتر نتایج به سال:
ریحان(ocimum basilicum l.) از گیاهان دارویی تیره نعناع و سرشار از ترکیبات فنیل پروپانوئیدی است. در این تحقیق به منظور مطالعه تأثیر متیل جاسمونات بر بیان ژن های چاویکول-o-متیل ترنسفراز(cvomt) و سینامات چهار هیدروکسیلاز (c4h) (ژن های کلیدی دخیل در بیوسنتز فنیل پروپانوئیدها) و آنزیم های آنتی اکسیدانت آسکوربات پراکسیداز و گایاکول پراکسیداز در گیاه ریحان رقم کشکنی لولو، آزمایشی بر پایه طرح کاملاً تصا...
The clinical overlap between monogenic Familial Hemiplegic Migraine (FHM) and common migraine subtypes, and the fact that all three FHM genes are involved in the transport of ions, suggest that ion transport genes may underlie susceptibility to common forms of migraine. To test this leading hypothesis, we examined common variation in 155 ion transport genes using 5257 single nucleotide polymorp...
Matrix metalloproteases (MMPs) are endopeptidases that regulate diverse biological processes. Synthesized as zymogens, MMPs become active after removal of their prodomains. Much is known about the metalloprotease activity of these enzymes, but noncanonical functions are poorly defined, and functions of the prodomains have been largely ignored. Here we report a novel metalloprotease-independent,...
The short QT syndrome is a newly discovered pro-arrhythmic condition, which may cause ventricular fibrillation and sudden death. Short QT can originate from the apparent gain-of-function mutation N588K in the hERG potassium channel that conducts repolarising I(Kr) current. The present study describes a profound biophysical characterization of HERG-N588K revealing both loss-of-function and gain-...
MinK-related protein (MiRP1 or KCNE2) interacts with the hyperpolarization-activated, cyclic nucleotide-gated (HCN) family of pacemaker channels to alter channel gating in heterologous expression systems. Given the high expression levels of MiRP1 and HCN subunits in the cardiac sinoatrial node and the contribution of pacemaker channel function to impulse initiation in that tissue, such an inter...
BACKGROUND Numerous structurally unrelated drugs, including antipsychotics, can prolong QT interval and trigger the acquired long QT syndrome (aLQTS). All of them are thought to act at the level of KCNH2, a subunit of the potassium channel. Although the QT-prolonging drugs are proscribed in the subjects with aLQTS, the individual response to diverse QT-prolonging drugs may vary substantially. ...
باکتریهای لومینسانس در انواع مختلفی از محیط های طبیعی یافت می شود. این باکتریها اهمیت ویژه ای از جنبه های اکولوژیکی و بیوتکنولوژی دارند. در این مطالعه سعی گردید تا حضور یا عدم حضور باکتریهای لومینسانس در حوضچه های طبیعی پرورش میگو که با آب خیلج فارس مرتبط هستند مورد بررسی قرار گرفته و خصوصیات مختلف مورفولوژیکی و بیوشیمیایی آنها مورد بررسی قرار گیرد. علاوه بر روشهای متداول میکروبیولوژیکی از ژن 1...
lentinan a polysaccharide from medicinal mushroom i.e lentinus, has been known to have anticancer properties. telomerase activity is not observed in normal healthy cells, whereas in cancerous cells telomerase expression is high. telomerase represents a promising cancer therapeutic target. we investigated the inhibitory effect of lentinan on telomerase reverse transcriptase gene (htert) which is...
lentiviral vectors are promising gene delivery tools capable of transducing a variety of dividing and non-dividing cells, including pluripotent stem cells which are refractory for transduction by murine retroviruses. although there is a growing debate on the safety of lentiviral vectors for gene transfer, in particular for those derived from human immunodeficiency viruses, type one (hiv-1) and ...
abstract background: schizophrenia is a severe mental disorder and numerous genes and loci are beleived to be involved in this disease. recent studies have reported a strong genetic association between dtnbp1 (dystrobrevin-binding protein 1) gene variants and schizophrenia. methods: in this research, we used a case-control study to establish the possible association between the p1635 (rs3213207...
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