نتایج جستجو برای: kcs number

تعداد نتایج: 1168822  

2012
Shashi Bala Gyongyi Szabo

Alcoholic liver disease (ALD) is a major global health problem. Chronic alcohol use results in inflammation and fatty liver, and in some cases, it leads to fibrosis and cirrhosis or hepatocellular carcinoma. Increased proinflammatory cytokines, particularly TNF alpha, play a central role in the pathogenesis of ALD. TNF alpha is tightly regulated at transcriptional and posttranscriptional levels...

2014
Hui Wang Lei Wang Nan-lin Li Jun-tang Li Feng Yu Ya-li Zhao Ling Wang Jun Yi Ling Wang Jie-fang Bian Jiang-hao Chen Shi-fang Yuan Ting Wang Yong-gang Lv Ning-ning Liu Xiao-shan Zhu Rui Ling Jun Yun

Volatile anesthetic isoflurane (ISO) has immunomodulatory effects. The fungal component zymosan (ZY) induces inflammation through toll-like receptor 2 or dectin-1 signaling. We investigated the molecular actions of subanesthetic (0.7%) ISO against ZY-induced inflammatory activation in murine Kupffer cells (KCs), which are known as the resident macrophages within the liver. We observed that ISO ...

Journal: :Fundamenta Informaticae 2022

An operating system kernel uses cryptographically secure pseudorandom number generator (CSPRNG) for creating address space layout randomization (ASLR) offsets to protect memory addresses of processes from exploitation, storing users’ passwords securely and cryptographic keys. However, at present, popular CSPRNGs such as Yarrow, Fortuna /dev/(u)random which are used by MacOS/iOS/FreeBSD, Windows...

2018
Jun Sun An Qi Xu Julia Giraud Haiko Poppinga Thomas Riemensperger André Fiala Serge Birman

Startle-induced locomotion is commonly used in Drosophila research to monitor locomotor reactivity and its progressive decline with age or under various neuropathological conditions. A widely used paradigm is startle-induced negative geotaxis (SING), in which flies entrapped in a narrow column react to a gentle mechanical shock by climbing rapidly upwards. Here we combined in vivo manipulation ...

Journal: :Current Biology 2015
Divya Sitaraman Yoshinori Aso Xin Jin Nan Chen Mario Felix Gerald M. Rubin Michael N. Nitabach

The Drosophila mushroom body (MB) is a key associative memory center that has also been implicated in the control of sleep. However, the identity of MB neurons underlying homeostatic sleep regulation, as well as the types of sleep signals generated by specific classes of MB neurons, has remained poorly understood. We recently identified two MB output neuron (MBON) classes whose axons convey sle...

2013
David L. Williams Brenda K. Mann

Keratoconjunctivitis sicca, commonly referred to as dry eye or KCS, can affect both humans and dogs. The standard of care in treating KCS typically includes daily administration of eye drops to either stimulate tear production or to hydrate and lubricate the corneal surface. Lubricating eye drops are often applied four to six times daily for the life of the patient. In order to reduce this dosi...

Journal: :Frontiers in Systems Neuroscience 2008
Paul Szyszka Alexander Galkin Randolf Menzel

The insect mushroom bodies are higher-order brain centers and critical for odor learning. We investigated experience dependent plasticity of their intrinsic neurons, the Kenyon cells (KCs). Using calcium imaging, we recorded KC responses and investigated non-associative plasticity by applying repeated odor stimuli. Associative plasticity was examined by performing appetitive odor learning exper...

2017
David Williams Heather Hewitt

This study evaluates tear ferning as an ancillary technique for the evaluation of the canine tear film in normal eyes and eyes affected by keratoconjunctivitis sicca (KCS). Thirty dogs with KCS and 50 control dogs with normal tear film were evaluated with a full ophthalmoscopic examination and a Schirmer tear test type 1 (STT) determined before tear samples were obtained from the medial canthus...

Journal: :Environmental toxicology and chemistry 2005
Isamu Ogura Masashi Gamo Shigeki Masunaga Junko Nakanishi

The major sources of dioxin-like polychlorinated biphenyls (PCBs) in two sediment cores from Tokyo Bay and Lake Shinji (both in Japan) were identified and their source contributions estimated using two receptor models. The first was a nonnegative constrained factor analysis (FA) model, and the second was a nonnegative constrained chemical mass balance model combined with Monte Carlo techniques ...

Journal: :PLoS Computational Biology 2008
Luca A. Finelli Seth Haney Maxim Bazhenov Mark Stopfer Terrence J. Sejnowski

Neural circuits exploit numerous strategies for encoding information. Although the functional significance of individual coding mechanisms has been investigated, ways in which multiple mechanisms interact and integrate are not well understood. The locust olfactory system, in which dense, transiently synchronized spike trains across ensembles of antenna lobe (AL) neurons are transformed into a s...

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