Measurement of the rate of accumulation of radioiodine by the thyroid gland is of considerable clinical value, since in most instances an avid uptake of radioiodine may be correctly assumed to be due to a high rate of uptake of stable iodide by the thyroid. This measurement, expressed as a percentage of the administered radioiodine dose accumulated per unit time by the thyroid, does not give a ...

It has been known for many years that administered iodide appears in the milk of lactating animals. The early work on this subject was reviewed in 1937 by Elmer (1). Since that time, ample confirmation that the mammary gland secretes iodine has been obtained through experiments with radioactive iodide in man (Z-5) and a variety of animals (6-14). In rabbits (6, 8, 9) and goats (6), it has been ...

In 1948, Wolff and Chaikoff reported that organic binding of iodide in the thyroid was decreased when plasma iodide levels were elevated (acute Wolff-Chaikoff effect), and that adaptation or escape from the acute effect occurred in approximately 2 days, in the presence of continued high plasma iodide concentrations. We later demonstrated that the escape is attributable to a decrease in iodide t...

Previous studies have suggested that phytoplankton play an important role in the biogeochemical cycling of iodine, due to the appearance of iodide in the euphotic zone. Changes in the speciation of iodine over the course of the growth cycle were examined in culture media for a variety of phytoplankton taxa (diatoms, dinoflagellates and prymnesiophytes). All species tested showed the apparent ab...

In this article Pendred's syndrome, which is the combination of - congenital goitre with deafmutism, is discussed. This type of goitre is due to a special enzymatic defect, involving  a process of hormonogenesis, which is respon-· sible for the incorporation of iodide in the tyrosine molecule.  A case of pendred's syndrome is presented  in a 16-year-old girl. This girl has never been able to...

The importance of dietary iodide on the reported hypothyroid effect of drinking water disinfectants on thyroid function was investigated. Previous studies have also showed differences in the relative sensitivity of pigeons and rabbits to chlorinated water. Pigeons and rabbits were exposed for 3 months to diets containing high (950 ppb) or low (300 ppb) levels of iodide and to drinking water con...