BACKGROUND Local injections of anesthetics, NSAIDs, and corticosteroids for tendinopathies are empirically used. They are believed to have some cytotoxicity toward tenocytes. The maximal efficacy dosages of local injections should be determined. A commercial 2D microfluidic xCELLigence system had been developed to detect real-time cellular proliferation and their responses to different stimuli ...

Nanoemulsions (NE) are isotropic, dispersions of oil, water, surfactant(s) and cosurfactant(s). A range components (11 surfactants, nine cosurfactants, five oils) were investigated as potential excipients for preparation ketorolac tromethamine (KT) ocular nanoemulsion. Diol cosurfactants the effect their carbon chain length dielectric constant (DEC), Log P, HLB on saturation solubility KT. Hen’...

Microparticles loaded gels (MPLGs) are colloidal drug carriers in the microand submicron range. These systems were developed to overcome solubility problems of poorly soluble drugs as well as for long acting injectable depot formulations and specific drug targeting options. The main objective for these systems was to improve the classical aqueous eye drop formulations which have major disadvant...