Protective effect of Curculigo orchioides in streptozotocin and nicotinamide-induced diabetic neuropathic pain Wistar ratsKrishan Singla, Randhir Singh

Background: This study aimed to investigate the possible apoptotic role of bortezomib (BMZ) on pancreatic islets streptozotocin (STZ)-induced diabetic rats.

In the present study, the effect of minocycline was studied against intracerebroventricular streptozotocin induced spatial memory deficit. Male wistar rats were injected with intracerebroventricular streptozotocin bilaterally. The rats were treated chronically with Minocycline (10, 20 and 40 mg/kg, ip) for 17 days starting from day 1 of streptozotocin injection in separate groups. The spatial m...

This paper proposes an emotion recognition system. Human emotion can be expressed through many kinds of medium such as speech, image, facial expression, and so forth. This paper focuses on the textual data of them. Proposed system is a hybrid system that uses alternatively two methods, keyword-based and machine learning method. Keyword-based methods are traditional approaches using emotional ke...

The diabetogenic activity of streptozotocin has been correlated with a reduction in pyridine nucleotide synthesis in the mouse pancreatic islet. To determine the specificity of this reduction for diabetogenicity, a comparative study of streptozotocin, its cytotoxic moiety, 1-methyl-1-nitrosourea, and alloxan was performed. Streptozotocin administered intraperitoneally (i.p.) producd a dose-rela...

This study investigates whether experimental diabetes alters the ease with which platelet aggregation can be initiated in pial and mesenteric microvessels of the mouse. Aggregation was elicited by exposing microvessels to radiant energy from a mercury lamp in the presence of sodium fluorescein. The time required for this noxious stimulus to initiate aggregation was similar in fed or fasted allo...

Infrared Functional Imaging was applied to the study of Raynaud’s Phenomenon obtaing a simultaneous assessment of the thermal properties of all five fingers of both hands of a group of patients with respect of a control group. The method is based on the use of high-resolution telethermography imaging and allows identification of objective parameters from the re-warming curves of finger immediat...

Alloxan and streptozotocin are widely used to induce experimental diabetes in animals. The mechanism of their action in B cells of the pancreas has been intensively investigated and now is quite well understood. The cytotoxic action of both these diabetogenic agents is mediated by reactive oxygen species, however, the source of their generation is different in the case of alloxan and streptozot...

Diabetes mellitus (DM) is caused by either destruction of pancreatic β-cells (type 1 DM) or unresponsiveness to insulin (type 2 DM). Conventional therapies for diabetes mellitus have been developed but still needs improvement. Many diabetic patients have complemented conventional therapy with alternative methods including oral supplementation of natural products. In this study, we assessed whet...

In the present study, the effect of antioxidants-alpha lipoic acid, melatonin and trans resveratrol were studied against intracerebroventricular streptozotocin induced spatial memory deficit. Male Wistar rats were injected with intracerebroventricular streptozotocin bilaterally. The rats were treated chronically with alpha lipoic acid (200 mg/kg, po), melatonin (20 mg/kg, ip) and trans resverat...