Many questions remain regarding vitamin A (VA) supplementation of infants. Herein we compared direct oral VA supplementation of the neonate and indirect treatment through maternal dietary VA (M-VA) treatment on VA status and kinetics in neonatal rats. Treatments included direct VA combined with retinoic acid (RA) [D-VARA; VA (6 mg/kg) + 10% RA, given orally to neonates on postnatal day (P)2 and...

+*Patwardhan, A (A-VA RR&D); **Carandang, G (A-VA RR&D); *Ghanayem, A (A-VA RR&D); **Voronov, L; **Havey, R (A-VA RR&D); ***Phillips, F; ***Cunningham, B; **Simonds, J (A-VA RR&D); **Meade, K (A-VA RR&D); **Lim, T (A-VA RR&D); **Gavin, T; *Zindrick, M +*Loyola University Medical Center, Maywood, IL. Department of Orthopaedic Surgery, 2160 S. First Avenue, Maywood, IL 60153, 708-202-5804, Fax: 7...

PURPOSE To determine photopic and mesopic distance high-contrast visual acuity (HC-VA) and low-contrast visual acuity (LC-VA) in eyes with early age-related macular degeneration (AMD). METHODS Measurements were made in 22 subjects with early AMD and 28 healthy control subjects. Inclusion criteria included a photopic HC-VA of 20/25 or better. Distance VA was measured using HC (96%) and LC (10%...

Extracts of Viscum album (VA); a semi-parasitic plant, are frequently used in the complementary therapy of cancer and other immunological disorders. Various reports show that VA modulates immune system and exerts immune-adjuvant activities that might influence tumor regression. Currently, several therapeutic preparations of VA are available and hence an insight into the mechanisms of action of ...

OBJECTIVES We administered pilsicainide chloride, a class Ic pure sodium channel blocker, to patients with Brugada syndrome (BS) and evaluated the occurrence of ventricular arrhythmia (VA) and T-wave alternans (TWA). BACKGROUND Ventricular arrhythmia and TWA are sometimes induced by a sodium channel blocker challenge test in BS patients, but the significance of the induced VA and TWA is not k...

BACKGROUND To simulate the short-term dynamics of soluble gas exchange (e.g. CO2 rebreathing), model structure, ventilation-perfusion (VA/Q) and ventilation-volume (VA/VA) parameters must be selected correctly. Some diseases affect mainly the VA/Q distribution while others affect both VA/Q and VA/VA distributions. Results from the multiple inert gas elimination technique (MIGET) and multiple br...

The relation between vitamin A (VA) nutritional status and the metabolism of all-trans-retinoic acid (RA) is not well understood. In this study, we determined the tissue distribution and metabolism of a test dose of [(3)H]-RA in rats with graded, diet-dependent, differences in VA status. The design included 3 groups, designated VA-deficient, VA-marginal, and VA-adequate, with liver total retino...

Among Veterans, heart failure (HF) contributes to frequent emergency department visits and hospitalization. Dual health care system use (dual use) occurs when Veterans Health Administration (VA) enrollees also receive care from non-VA sources. Mounting evidence suggests that dual use decreases efficiency and patient safety. This qualitative study used constructivist grounded theory and content ...