Surface plasmon resonance biosensor technology was used to directly measure the binding interactions of small molecules to the ligand-binding domain of human estrogen receptor. In a screening mode, specific ligands of the receptor were easily discerned from nonligands. In a high-resolution mode, the association and dissociation phase binding responses were shown to be reproducible and could be ...

UNLABELLED Compartment models are the basis for most physiologically based quantification of nuclear medicine data. Although some software packages are available for this purpose, many are expensive, run on relatively few types of computers or are of limited capability, and cannot be extended because of the unavailability of source code. Consequently, institutions with modeling expertise often ...

E-learning is popularized so fast and Collaborative Learning (CL) becomes so important an instructional strategy. There are huge Group Session (GS) texts needed to be analyzed to evaluate CL, thus the automatic or semi-automatic methods of analyzing the GS texts become very important. In this paper we present a method called Interaction Analysis depended on Knowledge Extraction (IAKE) to analyz...

We discuss various properties of the ground state of a Bose-condensed dilute gas confined by an external potential. We devote particular attention to the role played by the interaction in determining the kinetic energy of the system and the aspect ratio of the velocity distribution. The structure of the wave function near the classical turning point is discussed and the drawback of the Thomas-F...

Introduction: The key characteristics of positron emission tomography (PET) are its quantitative capability and its sensitivity, which allow the in vivo imaging of biochemical interactions with small amounts of tracer concentrations. Therefore, accurate quantification is important. However, it can be sensitive to several physical factors. The aim of this investigation is the assessment of the e...

The dynamics of the chemotactic peptide receptor on rabbit peritoneal polymorphonuclear leucocytes were followed using the tritiated peptide N-formylnorleucylleucylphenylalanine (FNLLP). We have used a kinetic analysis to examine the possible interrelationships between receptor loss (down-regulation), receptor-mediated peptide uptake, and receptor recycling. We have previously demonstrated that...

The kinetic properties of rabbit liver tRNA nucleotidyltransferase were examined. Our results indicate that incorporation of AMP into tRNA-C-C at pH 9.4 proceeds by a rapid equilibrium Random Bi Bi mechanism. This conclusion was supported by bisubstrate initial velocity studies, dead end and product inhibition, and isotope exchange at equilibrium and during the net reaction. This analysis has m...

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