Monolayers of different gangliosides (GMI , Gnla, GDtb, GTIb, GMix) , ceramide (Cer), sulfatide (Suif), phospholipids (DOPC, DPPE, DPPS, DOPA), a quaternary ammonium salt (DOMA) and fatty acids (Ct6, Cis, Cze ) were investigated at the air/water interface on pure water as well as on buffered subphases. Monolayers at the air/water interface consist of two interfaces: the water/lipid and the lipi...

The density-distribution patterns of various enzymes and of labeled materials have been determined by isopycnic centrifugation in a sucrose-0.2 M KC1 gradient on homogenates of lymphoid tissues from rats injected with Triton WR-1339, 14C-labeled dextran, 51Cr-labeled erythrocytes, and cortisol. The results confirm and extend the conclusion, derived from previous investigations on normal animals...

Over a 10-year period, l30 consecutive cases of brucellosis were encountered and were prospectively treated and followed. Twenty-one cases were children and the remainder were adults. There were 93 males and 37 females with a male: female ratio of 2.5 to one. The age range of the patients was from 2 to 74 years with a mean of 30 years. Fifty-five percent of cases were from rural areas and ...

Prostate cancer is the most common solid tumor among men in Western industrialized countries. A major problem in prostate cancer treatment is the development of androgen-independence, as androgen-deprivation therapy is the basic therapy for the disease. Molecular mechanisms behind prostate cancer and androgen-independent growth development are poorly known. In this study, subtractive hybridizat...

BACKGROUND Amoxicillin is a commonly used antibiotic which has a short half-life in human. The frequent administration of amoxicillin is often required to keep the plasma drug level in an effective range. The short dosing interval of amoxicillin could also cause some side effects and drug resistance, and impair its therapeutic efficacy and patients' compliance. Therefore, a three-pulse release ...

The present study was aimed to develop an extended release tablet of Metoprolol Succinate for the treatment of hypertension. Four extended release formulations F1-F4 were developed using varying proportions of Hydroxyl propyl methyl cellulose K100M, Sodium carboxy methyl cellulose and Eudragit L30 D55 by wet granulation. Five extended release formulations F5-F9 containing HPMC K100M and HPMC 5c...