نتایج جستجو برای: lactam
تعداد نتایج: 6613 فیلتر نتایج به سال:
Abstract Objective: Compare outcomes of patients receiving high-dose oral beta-lactam versus standard therapy for Enterobacterales bacteremia from a urinary tract infection (UTI). Design: Retrospective, multicenter, observational cohort. Setting: Three Michigan community teaching hospitals. Patients: Adult admitted between February 1, 2020, and October 2022, with gram-negative source were evalu...
BACKGROUND Systemic corticosteroids have anti-inflammatory effects, whereas macrolides also have immunomodulatory activity in addition to their primary antimicrobial actions. We aimed to evaluate the potential interaction effect between corticosteroids and macrolides on the systemic inflammatory response in patients with severe community-acquired pneumonia to determine if combining these two im...
Over hundred new a priori global/local molecular descriptors that encoded steric, topological, electronic, hydrogen bonding, compositional and hydrophobic properties were generated for 16 b-lactams, and two partial least squares regression models were constructed and cross-validated. These a priori models (Q > 0.80, R > 0.95, SEV < 0.50) are comparable with the previously obtained computed mode...
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