نتایج جستجو برای: lactamase

تعداد نتایج: 12815  

Journal: :Antimicrobial agents and chemotherapy 1997
P A Bradford C Urban N Mariano S J Projan J J Rahal K Bush

Six Escherichia coli and 12 Klebsiella pneumoniae isolates from a single hospital expressed a common beta-lactamase with a pI of approximately 9.0 and were resistant to cefoxitin and cefotetan (MIC ranges, 64 to > 128 and 16 to > 128 micrograms/ml, respectively). Seventeen of the 18 strains produced multiple beta-lactamases. Most significantly, three K. pneumoniae strains were also resistant to...

Journal: :Journal of Institute of Medicine 2021

Introduction In this era of modern medicine, antimicrobial resistance can be regarded as a major health calamity. The emergence multidrug-resistant (MDR) Pseudomonas aeruginosa strains poses therapeutic challenges and lead to treatment failure in hospitalized patients. This study was conducted determine various types β-lactamases among MDR P. isolates recovered from patients.
 MethodsThis ...

2017
Sabrina N Andreis Vincent Perreten Sybille Schwendener

Whole-genome sequencing of penicillin-resistant Staphylococcus arlettae strain SAN1670 from bovine mastitis milk revealed a novel β-lactamase operon consisting of the β-lactamase-encoding gene blaARL, the antirepressor-encoding gene blaR1ARL, and the repressor-encoding gene blaIARL. The functionality of blaARL was demonstrated by gene expression in Staphylococcus aureus. The blaARL operon was c...

2015
Duck Jin Hong Il Kwon Bae In-Ho Jang Seok Hoon Jeong Hyun-Kyung Kang Kyungwon Lee

Metallo-β-lactamase-producing Pseudomonas aeruginosa (MPPA) is an important nosocomial pathogen that shows resistance to all β-lactam antibiotics except monobactams. There are various types of metallo-β-lactamases (MBLs) in carbapenem-resistant P. aeruginosa including Imipenemase (IMP), Verona integron-encoded metallo-β-lactamase (VIM), Sao Paulo metallo-β-lactamase (SPM), Germany imipenemase (...

2017
ADRIAN BĂNCESCU GABRIELA BĂNCESCU ANDREEA DIDILESCU MIRCEA HÎRJĂU

The aim of this study was to investigate in vitro the antibiotic susceptibility of 53 strains of Prevotella isolated from vestibular abscesses. The E-test was used for determining the minimum inhibitory concentrations for: benzylpenicillin, ampicillin, amoxicillin/clavulanic acid, clindamycin and metronidazole. In addition to this, the beta-lactamase production was detected by the chromogenic c...

Journal: :jundishapur journal of microbiology 0
fereshteh raei department of microbiology, faculty of biological sciences, shahid beheshti university, general campus, tehran, ir iran fereshteh eftekhar department of microbiology, faculty of biological sciences, shahid beheshti university, general campus, tehran, ir iran; department of microbiology, faculty of biological sciences, shahid beheshti university, general campus, tehran, ir iran. tel: +98-2129903208, fax: +98-2122431664 mohammad mehdi feizabadi department of microbiology, school of medicine, tehran university of medical sciences, tehran, ir iran

background extended-spectrum β-lactamase (esbl) production is the major resistance mechanism to β-lactam antibiotics in enterobacteriaceae. in addition, emergence of plasmid-mediated quinolone resistance (pmqr) in esbl-producing isolates has become a global threat for treatment of these infections. objectives we investigated the association between esbl production and quinolone resistance in ur...

Journal: :The Biochemical journal 1998
S Lin M Thomas D M Shlaes S D Rudin J R Knox V Anderson R A Bonomo

The Met69-->Ile mutant of the OHIO-1 beta-lactamase, an SHV-family enzyme, is resistant to inactivation by beta-lactamase inhibitors. Analysis of purified Met69-->Ile enzyme reveals that its isoelectric point (pI 7.0) and CD spectrum are identical with those of the OHIO-1 enzyme. Levels of beta-lactamase expression in Escherichia coli as determined by immunoblotting are similar for OHIO-1 and M...

2015
Ai Fujita Kouji Kimura Satoru Yokoyama Wanchun Jin Jun-ichi Wachino Keiko Yamada Hiroyuki Suematsu Yuka Yamagishi Hiroshige Mikamo Yoshichika Arakawa Herman Tse

We characterized 12 clinical isolates of Klebsiella oxytoca with the extended-spectrum β-lactamase (ESBL) phenotype (high minimum inhibitory concentration [MIC] values of ceftriaxone) recovered over 9 months at a university hospital in Japan. To determine the clonality of the isolates, we used pulsed-field gel electrophoresis (PFGE), multi-locus sequence typing (MLST), and PCR analyses to detec...

Journal: :Antimicrobial agents and chemotherapy 1998
R K Voladri D L Lakey S H Hennigan B E Menzies K M Edwards D S Kernodle

New antibiotic regimens are needed for the treatment of multidrug-resistant tuberculosis. Mycobacterium tuberculosis has a thick peptidoglycan layer, and the penicillin-binding proteins involved in its biosynthesis are inhibited by clinically relevant concentrations of beta-lactam antibiotics. beta-Lactamase production appears to be the major mechanism by which M. tuberculosis expresses beta-la...

Journal: :Communicable diseases intelligence quarterly report 2013
Gino Micalizzi

Understanding the antibiotic susceptibility of Salmonella enterica is important both from a clinical treatment and a public health perspective. The emergence of extended spectrum ß-lactamases (ESßLs) and AmpC ß-lactamases in S. enterica is important, as this will limit treatment options and could provide a strain with a significant selective advantage. The aim of the study was to screen isolate...

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