IL-23 is a proinflammatory cytokine consisting of a p19 subunit and a p40 subunit that is shared with IL-12. IL-23 is overexpressed in and around tumor tissues, where it induces local inflammation and promotes tumor development. Many tumor cells produce large amounts of lactic acid by altering their glucose metabolism. In this study, we show that lactic acid secreted by tumor cells enhances the...

Biodegradable polymers have attracted much attention from an environmental point of view. Optically pure lactic acid that can be prepared by fermentation is one of the important raw materials for biodegradable polymer. The separation and purification of lactic acid from the fermentation broth are the major portions of the production costs. We proposed the application of supported ionic liquid m...

Industrial production of lactic acid with the current pyruvate decarboxylase-negative Saccharomyces cerevisiae strains requires aeration to allow for respiratory generation of ATP to facilitate growth and, even under nongrowing conditions, cellular maintenance. In the current study, we observed an inhibition of aerobic growth in the presence of lactic acid. Unexpectedly, the cyb2Delta reference...

The utilization of corn straw to produce lactic acid could largely save the resource as well as decrease the amount of agricultural waste. In this study, orthogonal experimental design was adopted to investigate the optimum conditions for cellulase production from corn straw, and then the cellulase was further used to produce lactic acid through simultaneous saccharification and fermentation (S...

H����� V., M������ K., R������� M. (2004): Modern method of lactic acid recovery from fermentation broth. Czech J. Food Sci., 22: 87–94. Electrodialysis was used for lactic acid recovery from fermentation broth. In the first step, lactate was recovered and concentrated by desalting electrodialysis, and the second step was electroconversion of lactate to lactic acid by water-splitting electrodia...

Lactic acid is an important chemical with various industrial applications, and it can be efficiently produced by fermentation, in which Bacillus coagulans strains present excellent performance. Betaine can promote lactic acid fermentation as an effective osmoprotectant. Here, positive effect of betaine on fermentation by B. coagulans is revealed. Betaine could enhance lactic acid production by ...

Fishmeal wastewater, a seafood processing waste, was utilized for production of lactic acid and fungal biomass by Rhizopus oryzae AS 3.254 with the addition of sugars. The 30 g/l exogenous glucose in fishmeal wastewater was superior to starch in view of productivities of lactic acid and fungal biomass, and COD reduction. Fishmeal wastewater can be a replacement for peptone which was the most su...

It was previously shown that the lactic dehydrogenases from various rabbit organs could be differentiated by immunochemical means (1). Vex11 and Ecarn (2) have reported that human serum contains lactic dchydrogenases with three differrnt electrophorctic mobilitics. Kaplan et al. (3), using the reaction rates in the presence of diphosphopyridinc nuclcotide and its analogues, have shown that the ...

D-lactic acid was produced by Sporolactobacillus sp. strain CASD in repeated batch fermentation with one- and two-reactor systems. The strain showed relatively high energy consumption in its growth-related metabolism in comparison with other lactic acid producers. When the fermentation was repeated with 10% (v/v) of previous culture to start a new batch, D-lactic acid production shifted from be...

cultures of lactic streptococci. J. Dairy Research, 5, 197-207. WHITEHEAD, H. R., AND COX, G. A. 1936 Bacteriophage phenomena in cultures of lactic streptococci. J. Dairy Research, 7, 55-62. WHITEHEAD, H. R., AND HUNTER, G. J. E. 1937 Observations on the activity of bacteriophage in the group of lactic streptococci. J. Path. Bacteriol., 44, 337-347. WHITEHEAD, H. R., AND HUNTER, G. J. E. 1947 B...