Neuromyelitis optica spectrum disorder (NMOSD) is a rare autoimmune disease, causing multifocal CNS inflammation affecting the optic nerves & spinal cord. In 20th century, ‘Devics disease’ was considered as variant of Multiple sclerosis(MS) that spared brain. However, discovery IgG-class antibodies bind to water channel aquaporin-4 (AQP4-IgG) in serum from patients with Devic’s but not thos...