Recent clinical studies on human skin indicated that in vivo multi-harmonic generation microscopy (HGM) can achieve sub-micron resolution for histopathological analysis with a high penetration depth and leave no energy or photodamages in the interacted tissues. It is thus highly desired to apply HGM for in vivo mucosa histopathological diagnosis. In this paper, the first in vivo optical virtual...

BACKGROUND The basement membrane of human colonic mucosa contains numerous discrete pores. We have recently shown that following loss of the surface epithelium, many cells migrate out of the colonic lamina propria via basement membrane pores. AIMS To characterise cells migrating out via basement membrane pores of the human gastric lamina propria, following loss of the surface epithelium. ME...

BACKGROUND Thromboxanes are produced in excess in inflammatory bowel disease. Preliminary reports suggest that ridogrel, a thromboxane synthase inhibitor, is anti-inflammatory and may have therapeutic benefits in patients with ulcerative colitis. AIMS To investigate the immunohistochemical expression of thromboxane synthase in the colorectal mucosa of patients with inflammatory bowel disease....

Pseudomelanosis duodeni is characterized by the presence of brownish or blackish pigmentation in the duodenal mucosa identified during endoscopy. Although the pathogenesis is uncertain, it was generally believed that it is sequelae of luminal absorption of iron and sulfide chemicals, which is subsequently deposited in the lamina propria. It is often associated with hemodialysis and oral intake ...

Caecal biopsy specimens from Jamaican children with the Trichuris dysentery syndrome (TDS) and age matched Jamaican controls were investigated by immunohistochemistry and by light microscopy. Biopsy specimens from all children (with TDS and controls) showed a mild to moderate increase in inflammatory cells. Except in the vicinity of the worm, where the epithelium was flattened, there was no oth...

The three-dimensional organization of the lymphatics in the dog stomach was studied by scanning electron microscopy of corrosion casts, which were made by direct parenchymal injection of low-viscosity Mercox-resin into the mucosa and the muscular layers. Although the organization of lymphatics in the stomach has been studied by a variety of methods, the origin of the lymphatics and their connec...

Cationized ferritin (CF) was injected interstitially to study the distribution of anionic sites on the basement membrane and abluminal aspect of the endothelium in the fenestrated capillaries of the mouse pancreas and intestinal mucosa. Extensive, but uneven removal of the basement membrane was obtained by collagenase perfusion of the vasculature before CF labeling. In the absence of collagenas...

OBJECTIVES This study evaluated the safety and effectiveness of injection of autologous fibroblasts into the lamina propria layer to treat vocal fold scarring. STUDY DESIGN A prospective, open-label, single arm, pilot study at a single tertiary care center. METHODS Autologous fibroblasts were expanded in cell culture from punch biopsies of the buccal mucosa of five human subjects with vocal...

Mast cells are found close to surfaces that interface with the external environment, particularly skin, respiratory, and digestive systems. The number of mast at a given site can vary depending on host's location immunologic status. This study was undertaken determine their heterogeneity in broilers' ileum during post-hatching period. were studied tissue 0-, 7-, 21- 42-day old broilers. stained...

Colonic angiodysplasia I was very interested by the suggestion by Roskell et al that colonic angiodysplasia may be related in some way to abnormalities in vascular basement membrane. The idea is appealing, and the illustration of staining for type IV collagen does indeed appear to show a diVerence between the strong positivity in submucosal vessels (fig 1A) and absence in the lamina propria ves...