نتایج جستجو برای: laminar shear box
تعداد نتایج: 168652 فیلتر نتایج به سال:
A volume-penalizing immersed boundary method is presented that facilitates the computation of incompressible fluid flow in complex flow domains. We apply this method to simulate the flow in cerebral aneurysms, and focus on the accuracy with which the flow field and the corresponding shear stress field are computed. The method is applied to laminar, incompressible flow in curved cylindrical vess...
In the setting of infection or wound healing, a tightly controlled pro-inflammatory and pro-thrombotic conversion of the endothelial phenotype is a beneficial biological response which helps to combat infection and renew organ integrity. However, prolonged endothelial activation, which has escaped control mechanisms of the host, may set off unfavorable sequelae, such as atherosclerosis and intr...
The respiratory pathogen Chlamydophila pneumoniae can be detected in atherosclerotic vessels, but the mechanism of dissemination from lung to vasculature remains unknown. Disturbance of vascular shear stress is a risk factor for atherosclerosis. We investigated whether polymorphonuclear neutrophils (PMN) might serve as carriers, transmitting C. pneumoniae to endothelial cells and how this is af...
The preferential association of cholesterol and sphingolipids within plasma membranes forms organized compartments termed lipid rafts. Addition of caveolin proteins to this lipid milieu induces the formation of specialized invaginated plasma membrane structures called caveolae. Both lipid rafts and caveolae are purported to function in vesicular transport and cell signaling. We and others have ...
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