Dynamic changes in internal light fluence were measured during interstitial laser heating of tissue phantoms and ex vivo bovine liver. In albumen phantoms, the results demonstrate an unexpected rise in optical power transmitted approximately I cm away from the source during laser exposure at low power (0.5-1 W), and a decrease at higher powers (1.5-2.5 W) due to coagulation and possibly charrin...

In this work, we investigate chemo- thermotherapy, a recently clinically-approved post-surgery treatment of non muscle invasive urothelial bladder carcinoma. We developed a mathematical model and numerically simulated the physical processes related to this treatment. The model is based on the conductive Maxwell's equations used to simulate the therapy administration and Convection-Diffusion equ...

BACKGROUND To develop a new procedure for laser prostatectomy through a biopsy needle, we evaluated the efficacy of interstitial laser irradiation with a pulsed Ho:YAG laser (lambda: 2.1 microns) in the normal canine prostate. METHODS Pathological studies were performed up to 6 months after interstitial laser irradiation in 26 mongrel dogs (15.4 +/- 2.6 kg). Two dogs underwent the identical p...

Background We evaluated the control rate of choroidal melanomas treated with Ru plaque brachytherapy to identify the risk factors associated with local recurrence and lack of response. Methods A retrospective review of Ru plaque brachytherapy for patients with choroidal melanoma treated at St Bartholomew’s Hospital, London. Survival analysis was used to assess associations between evaluated age...

PURPOSE To evaluate individual tumor control following chemoreduction for retinoblastoma. METHODS Prospective nonrandomized single-center case series of 457 retinoblastomas managed with six cycles of chemoreduction (vincristine, etoposide, and carboplatin). The tumors were then managed with chemoreduction alone (group A) or chemoreduction combined with thermotherapy (group B), cryotherapy (gr...

This study was designed to investigate the proliferation inhibition and apoptosis-promoting effect under hyperthermia and chemotherapy treatment, at cellular level. Human gastric cancer cell line SGC-7901 was cultivated with 5-fluorouracil at different temperatures. Cell proliferation and apoptosis were determined, and expression of Bcl-2 and HSP70 was measured at different treatments. Cell sur...