OBJECTIVE To correlate the cytologic diagnoses of peritoneal washings (PWs) with histologic findings of ovarian tumors of low malignant potential (LMP). METHODS PW cytology from 90 patients with histologically confirmed ovarian tumors of LMP were reviewed and correlated with histologic findings. RESULTS In 90 LMP tumor patients who underwent PW, cytologic diagnoses were reported as positive...

Lysosome associated membrane proteins (LAMPs) constitute a family of vertebrate proteins located predominantly in lysosomes, with lesser amounts present in endosomes and at the cell surface. Macrosialin/CD68s are similar to LAMPs in their subcellular distribution and amino acid sequence and presumed structure across the carboxyl terminal two thirds of their length. The functions of LAMPs and CD...

Lysosomal membrane permeabilization (LMP) is emerging as an important regulator of cell apoptosis. Human neutrophils are highly granulated phagocytes, which respond to pathogens by exhibiting increased production of reactive oxygen species (ROS) and lysosomal degranulation. In a previous study, we observed that intracellular, nonphagosomal generation of ROS triggered by adherent bacteria induce...

Investigation on the pectic substances of cashew (Anacardium occidentale L.) apple under different acid-extraction conditions (pH 1.0, 1.5, and 2.0) showed that more than 10%-25% of A. occidentale pectins (AOP) could be extracted, depending on the extractant strength. The extracted AOP contained high amounts of galacturonic acid (GalA: 69.9%-84.5%) with some neutral sugars of which rhamnose (Rh...

The Link Management Protocol (LMP) has been developed as part of the Generalized MPLS (GMPLS) protocol suite to manage Traffic Engineering (TE) resources and links. The GMPLS control plane (routing and signaling) uses TE links for establishing Label Switched Paths (LSPs). This memo describes the relationship of the LMP procedures to ’discovery’ as defined in the International Telecommunication ...

BACKGROUND The match play patterns in equestrian polo are unique and require specific training programs to ensure sport performance. The effect of commonly used exercise training regimens on the adaptation of skeletal muscle is unclear. The present study investigated the modulating effects of the classic training regimen, comprised of aerobic exercise training with increasing exercise intensiti...

Novel topoisomerase I (Top1) inhibitors are in clinical development to circumvent the drawbacks of camptothecins (CPT). Here, we report molecular investigations into LMP-400, an indenoisoquinoline Top1 inhibitor in phase 1 clinical trial, by itself and in combination with the cell-cycle checkpoint inhibitor AZD7762. We examined drug effects on DNA replication and killing of cancer cells and fou...

Anti-latent membrane protein-1 (LMP-1) is an EBV-encoded type III integral membrane protein with oncogenic potential that is expressed most consistently in various EBV-associated malignancies. Unlike many other EBV proteins, LMP-1 Abs have rarely been demonstrated in EBV-associated disease conditions. We established a high level LMP-1-expressing cell clone and used it for the detection, quantit...

Epstein-Barr virus (EBV) infection is associated with many human malignancies. In vitro, EBV transforms primary B lymphocytes into continuously growing lymphoblastoid cell lines. EBV latent membrane protein 1 (LMP-1) is required for EBV transformation processes. Interferon regulatory factor 4 (IRF-4) is a transcription factor and has oncogenic potential. We find that high levels of IRF-4 are as...

Tonsils, which exposed continually to antigens, are the important site for recurrent inflammation in the pediatric population. The purpose of this study was to investigate the presence of Epstein-Barr virus (EBV) in children’s tonsils, and to reveal the potential infection mechanism correlation with latent membrane protein 1 (LMP-1) encoded by EBV in human tonsil epithelial cell (HTEpiC). Polym...