نتایج جستجو برای: latent tuberculosis infection
تعداد نتایج: 584361 فیلتر نتایج به سال:
Nonhuman primates were used to develop an animal model that closely mimics human Mycobacterium tuberculosis infection. Cynomolgus macaques were infected with low doses of virulent M. tuberculosis via bronchoscopic instillation into the lung. All monkeys were successfully infected, based on tuberculin skin test conversion and peripheral immune responses to M. tuberculosis antigens. Progression o...
Tuberculosis has re-emerged as a serious public health threat worldwide because of a significant increase in multiple drug resistant Mycobacterium tuberculosis varieties and a synergy between HIV and M. tuberculosis infection. It has been over 40 years since a new drug for tuberculosis has been discovered. The increasing emergence of drug resistant TB, and HIV infection, which compromises host ...
BACKGROUND Complement functions as an important host defense system and complement C5 and C7 have been implicated in immunopathology of tuberculosis. However, little is known about the role of other complement components in tuberculosis. METHODS Complement gene expression in peripheral blood mononuclear cells of tuberculosis patients and controls were determined using whole genome transcripti...
With nearly 9 million new active disease cases and 2 million deaths occurring worldwide every year, tuberculosis continues to remain a major public health problem. Exposure to Mycobacterium tuberculosis leads to active disease in only ~10% people. An effective immune response in remaining individuals stops M. tuberculosis multiplication. However, the pathogen is completely eradicated in ~10% pe...
BACKGROUND In the United States, an increasingly disproportionate burden of tuberculosis among the foreign-born population has led to calls for improvements in the detection and treatment of latent infection in new immigrants. Current treatment guidelines do not take into account global differences in drug-resistance patterns or their implications for the treatment of immigrants. The use of mul...
One third of the world's population is estimated to be infected with Mycobacterium tuberculosis, representing a huge reservoir of potential tuberculosis (TB) disease. Risk of progression to active TB is highest in those with HIV coinfection. However, the nature of the host-pathogen relationship in those with "latent TB infection" and how this is affected by HIV coinfection are poorly understood...
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