BACKGROUND Langerhans cell histiocytosis (LCH) is a proliferative disease of histiocyte-like cells that generally affects children. Immunohistochemistry is essential to obtain the correct diagnosis, and treatment protocols are controversial. OBJECTIVE Langerhans cell histiocytosis (LCH) is easy to be misdiagnosed because of its various clinic features and laboratory results. This research foc...

BACKGROUND Langerhans-cell histiocytosis (LCH) is a rare disease with features of chronic inflammation and it may also induce hypopituitarism, conditions associated with an increased risk of cardiovascular diseases. AIM Cardiovascular and metabolic risk profile investigation in multisystem LCH patients with and without anterior pituitary deficiency. DESIGN Prospective, observational study. ...

Erdheim-Chester disease (ECD) is a rare histiocytic disorder, characterized by the xanthomatous infiltration of tissues by CD68-positive and CD1a-/CD100-negative foamy histiocytes. In childhood, ECD is exceptionally rare, and only a dozen cases have been published so far. The cooccurence of Langerhans cell histiocytosis (LCH) and ECD is even rarer. Here, we report a 2-year-old boy, the youngest...

Background and objective: Langerhans cell histiocytosis (LCH) is a rare histiocytic proliferative disorder of unknown etiology and mainly affects young children. The histological feature is granuloma-like proliferation of langerhans-type dendritic cells. Although the possible role of viruses such as Epstein-Barr virus (EBV, Human Herpes virus -4</...

Abstract Background Langerhans cell histiocytosis (LCH) is an abnormal polyclonal proliferation of cells that affect different parts the body. Temporal bone involvement quite common among involved sites. The etiology unknown. Diagnosis based on symptoms, imaging, and histopathology. Especially LCH in temporal confused with acute or subacute otitis media. There are many treatment options LCH. Ca...

BACKGROUND Langerhans cell histiocytosis (LCH) is a rare disease that affects mainly young children, and which features granulomas containing Langerhans-type dendritic cells. The role of several human herpesviruses (HHV) in the pathogenesis of LCH was suggested by numerous reports but remains debated. Epstein-barr virus (EBV, HHV-4), & Cytomegalovirus (CMV, HHV-5) can infect Langerhans cells, a...

a case of a 3-year-old patient with osteolytic lesion in the lumbar region is presented. the clinic-radiological suspicion was infection, primary or metastatic tumor of spine. subsequently, a ct guided biopsy proved an eosinophilic granuloma of bone. following medical treatment after two month, there was improvement in patient medical status.

Background. There are increasing data of targeted therapy efficacy different types Langerhans cell histiocytosis (LCH) with inhibitors BRAF-specific serin-threonine kinase (BRAF-inhibitors) in cases BRAF V600E mutation published last years. At the same time there no use MAPK/ERK pathway (MEK-inhibitors) pediatric patients BRAF-negative forms LCH. Purpose study is to evaluate and safety MEK-inhi...

Langerhans cell histiocytosis (LCH) is a heterologous disease with a recognized disparity in incidence, affected sites and prognosis between adults and children. The recent identification of BRAFV600E mutations in LCH prompted the investigation of the frequency of these mutations in adult and childhood disease with the involvement of single or multiple sites in the present study. The study anal...