Background: Many studies have shown that a reduction in low-density lipoprotein cholesterol (LDL-C) is associated with lower risk of cardiovascular disease. It has been suggested that the reduction of cardiovascular risk is proportional to the reduction in LDL-C. However, cholesteryl ester transfer protein (CETP) inhibitors have not been shown to follow this pattern. These medications increase ...

A raised low-density lipoprotein (LDL) cholesterol (LDL-C) is one of the major risk factors for ath-erosclerotic cardiovascular disease (ASCVD) 1-3). Homozygous family hypercholesterolemia (HoFH) is a rare inherited disease characterized by markedly elevated levels of LDL-C, generally more than 500 mg/ dL when untreated, and a high risk of premature ASCVD 4). HoFH is caused by loss-of-function ...

The influence of type fish consumption on cardiovascular risk profiles was studied in Sri Lankan community. Achallenge experiment set up to do a research the omega-3 fatty acid content cardiovascularrisk healthy people. Hundred undergraduates (subjects) who were between ages 23 30 yearsand full time resident hostels Lanka, randomly selected for this study. students fed with fishcurry and fried ...

BACKGROUND The purpose of this study was to assess the feasibility of infrared (IR) spectroscopy for the simultaneous quantification of serum LDL-cholesterol (LDL-C) and HDL-cholesterol (HDL-C) concentrations. METHODS Serum samples (n = 90) were obtained. Duplicate aliquots (5 microL) of the serum specimens were dried onto IR-transparent barium fluoride substrates, and transmission IR spectra...

Background: Climate change is a serious threat to human wellbeing and development. Global reduction of meat intake key addressing climate other modern sustainability challenges. Plant-based mycoprotein-based substitutes are predicted play role in the intake; however, their impact on health unclear. The main objective this meta-analysis was assess short-term effects important cardiometabolic bio...

A systematic review and meta-analysis of Mendelian randomization studies using Medline, Cumulative Index to Nursing Allied Health Literature Complete, Scopus databases. Sixteen involving 34,050 patients with an abdominal aortic aneurysm (AAA) 2,205,894 controls were included. Meta-analyses suggested that a 1 standard deviation increase in high-density lipoprotein cholesterol (HDL-C) significant...

INTRODUCTION Lowering of low density lipoprotein (LDL) cholesterol (LDL-C) has been shown to be associated with significant reduction of adverse cardiovascular (CV) events. The 2013 ACC/AHA guidelines recommend high-intensity statin therapy to lower LDL-C levels by$ 50% with no specific target goal for adults at high risk for atherosclerotic CV diseases, andmoderate-intensity statin therapy to ...

Background and Objectives: Dyslipidemia is a family of lipoprotein metabolism disorders manifested by elevated total cholesterol (TC), low-density (LDL-C), triglycerides (TG), reduced high density (HDL-C) concentrations in the blood.[1] was defined according to criteria National Cholesterol Education Program Adult Treatment Panel III. Hypercholesterolemia declared for participants with either ˃...

Abstract This study aimed to investigate the effects of dietary supplementation with modified-hen-egg-yolk on plasma lipids and lipoprotein profiles in rats. During four-week-experiment, 64 Wistar rats were divided into four groups 16 (eight both sexes), fed commercial rat food (group C); containing 70% mixture 30% freshly cooked egg yolk originating from laying hen eggs 3% fish oil F); palm ol...

BACKGROUND Statin therapy influences not only low-density lipoprotein (LDL) cholesterol levels but also LDL-related biomarkers, including non-high-density lipoprotein cholesterol (non-HDL-C), apolipoprotein B, total number of LDL particles, and mean LDL particle size. Recent studies have identified many genetic loci influencing circulating lipid levels and statin-induced LDL cholesterol reducti...