A 67 year old patient underwent interventional cardiac catheterisation for cardiac angina. An 80% stenosis of the left anterior descending artery and a 90% stenosis of the posterior descending artery were stented. A distal stenosis of the left anterior descending artery was dilated. Catheterisation was performed via the right radial artery. The patient received a combination of clopidogrel, ace...

Four subfamilies of voltage-gated K"*" channels {Shaker, Shal, Shab and Shaw) have been defined that are present in many species to regulate neuronal excitability. The well characterized simple leech nervous system is ideal to study the roles K+ channels have in regulating neuronal circuits. As a starting point for studies to examine the role of K+ channels in well defined leech circuitry, we r...

A 67 year old patient underwent interventional cardiac catheterisation for cardiac angina. An 80% stenosis of the left anterior descending artery and a 90% stenosis of the posterior descending artery were stented. A distal stenosis of the left anterior descending artery was dilated. Catheterisation was performed via the right radial artery. The patient received a combination of clopidogrel, ace...

A 67 year old patient underwent interventional cardiac catheterisation for cardiac angina. An 80% stenosis of the left anterior descending artery and a 90% stenosis of the posterior descending artery were stented. A distal stenosis of the left anterior descending artery was dilated. Catheterisation was performed via the right radial artery. The patient received a combination of clopidogrel, ace...

Amiloride-sensitive Na+ absorption is a well-described feature of numerous transporting epithelia in vertebrates. Yet, very little is known about this important physiological process regarding invertebrates. In the present paper, we compare vertebrate Na+ absorption mediated by the amiloride-sensitive epithelial Na+ channel (ENaC) and its invertebrate counterpart. We used the dorsal skin of the...

BACKGROUND Leeches are commonly used in reconstructive surgery for the treatment of venous congestion in flaps. Documented mechanisms of action are (1) injection of the anticoagulant hirudin; (2) active suction of blood; and (3) passive oozing of the bite wound. Even though the benefits of leeches in venous congestion are widely accepted, little is known about their effects in mixed arterio-ven...

Leech neurons in culture sprout rapidly when attached to extracts from connective tissue surrounding the nervous system. Laminin-like molecules that promote sprouting have now been isolated from this extracellular matrix. Two mAbs have been prepared that react on immunoblots with a approximately equal to 220- and a approximately equal to 340-kD polypeptide, respectively. These antibodies have b...

In contrast to mammals, the medicinal leech Hirudo medicinalis can completely repair its central nervous system (CNS) after injury. This invertebrate model offers unique opportunities to study the molecular and cellular basis of the CNS repair processes. When the leech CNS is injured, microglial cells migrate and accumulate at the site of lesion, a phenomenon known to be essential for the usual...

Patient: Female, 42 Final Diagnosis: Leech bite Symptoms: - Medication: - Clinical Procedure: - Specialty: Infectious diseases. OBJECTIVE Unusual clinical course. BACKGROUND Hirudo medicinalis (H. Medicinalis), also referred to as the medical leech, not only has been used by alternative medicine s...