Cutaneous leishmaniasis (CL) is a public health problem on a global level because it affects the population of 88 countries. In Morocco, it is widely distributed, caused by Leishmania tropica, Leishmania major and Leishmania infantum rarely. The geographical distribution of different forms of leishmaniasis in Morocco is linked to well described bioclimatic zones. Over the past two decades, the ...

Background Despite the high prevalence and drug resistance of disease in Sistan and Baluchestan Province of Iran, the species of cutaneous leishmaniasis (CL) has not been identified. In the present study, cytochrome b (Cyt b) was used in Sistan and Baluchestan to find species of Leishmania in suspected patients of CL using PCR-RFLP and DNA sequencing. Methods This study was conducted from Oct...

BACKGROUND Leishmaniasis has been identified as a major public health problem in tropical and sub-tropical countries. The present study was aimed to investigate antileishmanial effects of various extracts of Berberis vulgaris also its active compoenent, berberine against Leishmania tropica and L. infantum species on in vitro experiments. METHODS In this study in vitro antileishmanial activity...

Several natural and hemisyntetic passifloricins were assayed against Leishmania panamensis amastigotes. High leishmanicidal activity as well as toxicity was observed. The structure of a new compound is also reported.

We report the 1st collection of Phlebotomus sergenti, a vector of the cutaneous and visceralizing forms of Leishmania tropica, from southern Egypt. Four female and 1 male P. sergenti were collected from unlit Centers for Disease Control light traps placed in a village on the Nile River, 6 km north of Aswan, Egypt, during studies conducted from 1998 to 1999. This extends the known distribution o...

The present study aims to evaluate the in vitro and in vivo antileishmanial activities of Pistacia khinjuk Stocks (Anacardiaceae) alcoholic extract and to compare its efficacy with a reference drug, meglumine antimoniate (MA, Glucantime), against Leishmania tropica and Leishmania major. This extract (0-100 µg/mL) was evaluated in vitro against promastigote and intracellular amastigote forms of ...