Tissue Plasminogen Activator 7351C/T Polymorphism and Lacunar Stroke To the Editor: Jannes et al1 reported that a polymorphism in the tissue plasminogen activator (tPA) gene ( 7351C/T) was associated with ischemic stroke in an Australian population. Stratification for stroke subtype demonstrated an association with lacunar infarction (OR: 2.7; 95% CI, 1.1 to 6.7), but not with other stroke subt...

OBJECTIVES Pathological and clinical data suggest that patients presenting with ischaemic lacunar syndromes may be a heterogenous group. Those with isolated lacunar infarction are thought to have localised atherosclerosis whereas in those with coexisting leukoaraiois a distinct diffuse small vessel vasculopathy may be the predominant underlying pathology. The ACE insertion/deletion (I/D) polymo...

BACKGROUND AND PURPOSE Both dementia and stroke are major health problems in Chinese societies. Stroke is a frequent cause of dementia. Only a few studies have been published on poststroke dementia (PSDE), none of which has investigated a consecutive stroke cohort in Asian patient populations. The objective of this study was to examine the prevalence and clinical correlates of PSDE in Chinese s...

offelucidate the relationship between postprandial hypotension (PPH) and asymptomatic cerebrovascular damage, we evaluated changes in blood pressure after a meal by 24-hour blood pressure monitoring in 70 hospitalized essential hypertensive patients aged >/=50 years. They received a diet containing standard nutritional ingredients with 120 mmol (7 g) NaCl and were free from medication for at le...

BACKGROUND AND PURPOSE Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), caused by mutations in the NOTCH3 gene, is the most common monogenic disorder causing lacunar stroke and cerebral small vessel disease (SVD). Fabry disease (FD) due to mutations in the GLA gene has been suggested as an underdiagnosed cause of stroke, and one feature is SV...

Background Intracranial arteriosclerosis has been increasingly recognized as an etiological factor contributing to cognitive impairment. Indigenous Tsimane and Moseten, Amerindians of the Bolivian Amazon with physically-active subsistence lifestyle, are reported have lower prevalence dementia (Gatz et al., Alzheimer’s Dement, In press) coronary artery disease (Kaplan al.,Lancet,2017) than Weste...